PharmPK Discussion - Winnonlin 2-compartment with additive error result

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On 21 Apr 2015 at 12:53:09, Thitinatcha Dedkaew (thitinatcha.aaa.HOTMAIL.COM) sent the message


Hi,

From my result, what is the Cl values ? (mean CrCL=55.9 mL/min)

best regards,
Thitinat

cfMicro(A1, Cl / V, Cl2 / V, Cl2 / V2)
                dosepoint(A1)
                C = A1 / V
                error(CEps = 1.74905)
                observe(CObs = C + CEps)
                stparm(V = tvV * exp(nV))
                stparm(V2 = tvV2 * exp(nV2))
                stparm(Cl = tvCl * CrCL^dCldCrCL * exp(nCl))
                stparm(Cl2 = tvCl2 * exp(nCl2))
                covariate(CrCL)
                fixef(tvV = c(, 11.4388, ))
                fixef(tvV2 = c(, 38.3854, ))
                fixef(tvCl = c(, 0.268316, ))
                fixef(tvCl2 = c(, 40.7458, ))
                fixef(dCldCrCL(enable=1) = c(, 0.631483, ))
                ranef(diag(nV, nCl, nV2, nCl2) = c(0.13227941, 0.13377461, 0.072570931, 3.304103))
}

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