PharmPK Discussion - Gender difference in CYP450 modulation in sprague-Dawley rats

• On 17 Mar 2016 at 14:43:26, rama krishna (rkbits96.-a-.GMAIL.COM) sent the message
  

  
  Dear all,
  
  Could anyone share the possible reasons for:
  
  1) why in general male rats are being used and/or preferred for CYP450 modulation
  (induction/inhibition) in vivo ?
  
  2) Is it mandatory to document gender differences in CYP450 modulation (and in toxicity studies in
  animal species especially rats) of a new chemical entity (NCE) at pre-clinical phase?
  
  Thanks & regards,
  
  Rachumallu Ramakrishna
  Research scholar, Pharmacokinetics & Metabolism division
  Central Drug Research Institute
  Lucknow, Uttar Pradesh
  India
  
  

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