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Could anyone share the possible reasons for:
1) why in general male rats are being used and/or preferred for CYP450 modulation
(induction/inhibition) in vivo ?
2) Is it mandatory to document gender differences in CYP450 modulation (and in toxicity studies in
animal species especially rats) of a new chemical entity (NCE) at pre-clinical phase?
Thanks & regards,
Research scholar, Pharmacokinetics & Metabolism division
Central Drug Research Institute
Lucknow, Uttar Pradesh
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