PharmPK Discussion - NONMEM table generation

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On 29 Jun 2016 at 08:42:10, Katragadda, Suresh (Suresh.Katragadda.-a-.pfizer.com) sent the message


Hi,
  I have a question about table generated in NONMEM. I am asking about PATAB. In the patab TABLE, as
you can see there are more than 1 row for each ID with similar parameter values. I am wondering if
there is a way to get for each ID only one parameter value as a single row. Here I am attaching
control stream along with sample table output.

Thanks,
Suresh

$PROBLEM run9.mod Anti-mAb antibody
$INPUT C TIME DAY_TIME CONC ID SEX ANALYTE AMT SPECIES MDV EVID DOSE CMT ADDL II STATUS WEIGHT ROUTE
MATRIX ATYPE YTYPE ADA DV
$DATA LNDV.csv IGNORE="C"
$SUBROUTINES ADVAN8 TOL=8

$MODEL
COMP=(CENTRAL)
COMP=(PERIPHAL)

$PK
            CL        =          THETA(1)*EXP(ETA(1)); L/hr/kg
            V1       =          THETA(2)*EXP(ETA(2)); L/kg
            Q         =          THETA(3); L/hr/kg
            V2       =          THETA(4); L/kg
            VMAX =         THETA(5)*EXP(ETA(3)); ug/hr/kg
            KM      =          THETA(6); ug/L
            KEL     =          CL/V1
            K12     =          Q/V1
            K21     =          Q/V2

$DES
            DADT(1)        =          -(KEL+K12)*A(1)-VMAX*A(1)/((KM*V1)+A(1))+K21*A(2)
            DADT(2)        =          K12*A(1)-K21*A(2) ;TISSUE COMPARTMENT

$ERROR
            CFR     =          A(1)/V1
            IPRD   =          CFR
            IF(IPRD.LE.0) IPRD = 0.001; Set some value             IPRE    =          LOG(IPRD)
            IRES    =          DV - IPRE
            W        =          THETA(7); RESIDUAL ERROR
            IWRE =          IRES/W
            Y          =          IPRE+W*ERR(1)

$THETA         (0,0.0001)    ;CL      ;1
$THETA         (0,0.04)         ;V1      ;2
$THETA         (0,0.0005)    ;Q        ;3
$THETA         (0,0.04)         ;V2      ;4
$THETA         (0,6)               ;Vmax            ;5
$THETA         (0,10000)     ;Km     ;6
$THETA         (0,0.35)                     ;W       ;7

$OMEGA      0.05               ;IIV_CL           ;1
$OMEGA      0.1                  ;IIV_V1          ;2
$OMEGA      0.1                  ;IIV_VMAX   ;3

$SIGMA  1 FIX ;ResFixed

$ESTIMATION  FILE=run9.ext
METHOD=1 PRINT=5 MAXEVAL=9999 NOABORT SIG = 3 POSTHOC INTER MSFO = MSFO.OUTPUTFILE

$COV COMP

$TAB ID DOSE TIME DV IWRE IPRE CWRES PRED            ONEHEADER NOPRINT FILE = sdtab9
$TAB ID SPECIES DRUG BWT CL V1 Q V2 VMAX KM W ETA1 ETA2 ETA3                     ONEHEADER NOPRINT
FILE = patab9

TABLE NO.  2
ID          ANALYTE     SPECIES     BWT         CL          V1          Q           V2          VMAX
       KM          W           ETA1        ETA2        ETA3
  2.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1187E-04  4.0364E-02  6.7638E-04  2.4016E-02
3.0348E+00  3.8624E+02  7.1776E-02 -9.2472E-04 -4.0806E-02 -2.0570E-01
  2.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1187E-04  4.0364E-02  6.7638E-04  2.4016E-02
3.0348E+00  3.8624E+02  7.1776E-02 -9.2472E-04 -4.0806E-02 -2.0570E-01
  2.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1187E-04  4.0364E-02  6.7638E-04  2.4016E-02
3.0348E+00  3.8624E+02  7.1776E-02 -9.2472E-04 -4.0806E-02 -2.0570E-01
  2.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1187E-04  4.0364E-02  6.7638E-04  2.4016E-02
3.0348E+00  3.8624E+02  7.1776E-02 -9.2472E-04 -4.0806E-02 -2.0570E-01
  2.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1187E-04  4.0364E-02  6.7638E-04  2.4016E-02
3.0348E+00  3.8624E+02  7.1776E-02 -9.2472E-04 -4.0806E-02 -2.0570E-01
  2.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1187E-04  4.0364E-02  6.7638E-04  2.4016E-02
3.0348E+00  3.8624E+02  7.1776E-02 -9.2472E-04 -4.0806E-02 -2.0570E-01
  7.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1195E-04  4.8032E-02  6.7638E-04  2.4016E-02
3.4449E+00  3.8624E+02  7.1776E-02 -2.2906E-04  1.3314E-01 -7.8963E-02
  7.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1195E-04  4.8032E-02  6.7638E-04  2.4016E-02
3.4449E+00  3.8624E+02  7.1776E-02 -2.2906E-04  1.3314E-01 -7.8963E-02
  7.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1195E-04  4.8032E-02  6.7638E-04  2.4016E-02
3.4449E+00  3.8624E+02  7.1776E-02 -2.2906E-04  1.3314E-01 -7.8963E-02
  7.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1195E-04  4.8032E-02  6.7638E-04  2.4016E-02
3.4449E+00  3.8624E+02  7.1776E-02 -2.2906E-04  1.3314E-01 -7.8963E-02
  7.0000E+00  4.8401E+06  0.0000E+00  4.0000E+00  1.1195E-04  4.8032E-02  6.7638E-04  2.4016E-02
3.4449E+00  3.8624E+02  7.1776E-02 -2.2906E-04  1.3314E-01 -7.8963E-02

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On 29 Jun 2016 at 09:53:25, Coen van Hasselt (coenvanhasselt.aaa.gmail.com) sent the message
```
Yes, add FIRSTONLY to the $TABLE line.

Coen
```
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On 29 Jun 2016 at 09:54:20, Bill Denney (bill.aaa.denney.ws) sent the message


Hi Suresh,

Just add FIRSTONLY to your $TAB entry like:

$TAB ID SPECIES DRUG BWT CL V1 Q V2 VMAX KM W ETA1 ETA2
ETA3                     ONEHEADER NOPRINT FIRSTONLY FILE = patab9

Also FYI, this type of question is often better suited for the NMUSERS
mailing list.

Have a good day,

Bill

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