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We performed the in-situ studies for intestine of developed nano
formulations and calculated ka using below formula.
lnXr = lnX0 - ka x t
t(1/2) = 0.693 x ka
For pure drug there is increase in ka and followed by saturation at 1.5hr
and for developed formulations ka was increased till 3.5 hrs and followed
The query was raised what is Peff from in-situ study. Can any one put
light on this aspect or any suggestions how to justify.
Can i say the absorption rate enhance with saturation times indicates
increase in permeability?
Your answer and feedback will help me us lot. Thanking you in advance.
PRASHANT B MUSMADE M. Pharm. Ph. D.
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