PharmPK Discussion - tmax - Parent and Metabolite

• On 11 May 2016 at 08:40:16, (Nagaraju.Poola.aaa.sunovion.com) sent the message
  

  	
  Hello,
  
  I have for a small molecule (oral administration) where the median tmax for the parent (7 hrs) drug
  is later than metabolite (4 hrs).
  
  Are there any examples of drugs that have similar phenomenon?  I have usually seen tmax for parent
  to be earlier than the metabolite.
  
  Thank you.
  
  Regards,
  Raju
  
  

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• On 12 May 2016 at 09:03:10, Theodor W. Guentert (theodor.guentert.-a-.bluewin.ch) sent the message
  

  
  Extensive first-pass effect leads to this phenomenon.
  Theodor W. Guentert
  
  

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