Back to the Top
We are conducting a clinical study using a combination of drug A and drug B
or placebo in tablet formulations. We wish to blind this study by placing
these tablets in a container for oral administration.
The historical device 'cachet' has been suggested. A cachet ranges in size
from 3/4 to 1/8 inch in diameter and consists of two concave pieces of wafer
made of flour and water. They are sealed by moistening the margins and
pressing pressing firmly together. Are these available? We need
approximately 11,000 of them.
Please share any experience regarding blinding techniques.
Thank-you for your assistance.
Derek A. Ganes, Ph.D.
Director, Biopharmaceutics
Biovail Corporation International
Contract Research Division
460 Comstock Road, Toronto, Ontario, Canada M1L 4S4
(416) 752-3636 Ext. 253, (416) 752-7610 (FAX)
76546.1530.-a-.compuserve.com, ganesda.at.the-wire.com
from: "Derek A. Ganes"
Back to the Top
Tablets in a capsule are the normal blinded supplies for this kind of study.
Back to the Top
Thank-you for your comments regarding the use of tablets in capsules for the
blinding of clinical supplies.
Unfortunately, the tablets can not be put in a reasonably sized capsule
because of the large diameter of one of the tablets. This is why the
'cachet' was suggested.
Derek A. Ganes, Ph.D.
Biovail Corporation International
from: "Derek A. Ganes"
Back to the Top
Hi !
In France, 'cachet' is still available. I know a company which can provide
you what you want :
Cooperative Pharmaceutique Francaise
32 Bd Victor Hugo
BP 294
44010 NANTES
FRANCE
Tel : +33 51821717
Fax : +33 51821700
|
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@lists.ucdenver.edu with "Blinding Clinical Studies" as the subject | Support PharmPK by considering my eBooks |
Copyright 1995-2014 David W. A. Bourne (david@boomer.org)