PharmPK Discussion - pKa for ketoconazole, PLEASE!!!

• On 1 Nov 1995 at 22:34:22, carloss (carloss.-at-.speedy.coacade.uv.mx) sent the message
  

  
  There are a young graduate student doing a research on extraction of
  ketoconazole (Nizoral) from soap, to estimate aging and caducity date
  for a pharmacological development of ketoconazole.
  
  Chemical Abstracts is not available locally... :(
  None of our sources of information have this data... :(
  Lange's Handbook of Chemistry was the only book with info related... but
  not for ketoconazole... :(
  
  She needs, specifically, the value of pKa for ketoconazole in acid and
  basic medium, the 2-fase binomial distribution for extraction or any
  technique related to determine both values...
  
  Thanks in advance from Universidad Veracruzana, Mexico.
  
  Carlos Alberto Sanchez Velasco
  Centro de Informacion y Documentacion para la Docencia y la Investigacion
  Universidad Veracruzana
  Xalapa, Veracruz
  MEXICO
  
  carloss.-at-.speedy.coacade.uv.mx
  
  

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• On 3 Nov 1995 at 10:00:36, Daniel M Canafax (canaf001.aaa.maroon.tc.umn.edu) (Dan Canafax) sent the message
  

  
  Carlos:  Dr. Mann and I studied the dissolution of keto in this article: 9.
  Carlson JA, Mann HJ, Canafax DM.  Effect of pH on ketoconazole
  disintegration and dissolution.  Am J Hosp Pharm 1983; 40:1334-1336.  We
  use a very basic spetrophotometric assay for this study.  Hope it helps
  you.
  
  Dan
  
  >There are a young graduate student doing a research on extraction of
  >ketoconazole (Nizoral) from soap, to estimate aging and caducity date
  >for a pharmacological development of ketoconazole.
  
  

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• On 10 Nov 1995 at 16:28:32, carloss (carloss.-a-.speedy.coacade.uv.mx) sent the message
  

  
  for your support to our search for pKa of ketoconazole...
  A weird question, I know, but that things happen...
  
  I don't have words to thank all of you:
  
  Margot Emery, J.J. Linden, Rand Flory, Dare Bugay and, specially, Paul
  Ritty, special thanks to John Dyson (thank you very much!), M.H. Haghighat,
  Roger Jelliffe, Karen Eichhorn (Librarian of Tacoma Public Library),
  Johnny Lau (muchisimas gracias, amigo), Ignacio Segarra and Daniel M.
  Canafax (many thanks, mister Daniel).
  
  Truely yours,
  
  Carlos Alberto Sanchez Velasco
  Centro de Informacion y Documentacion para la Docencia y la Investigacion
  Universidad Veracruzana
  Xalapa, Ver.
  MEXICO
  
  e-mail: carloss.aaa.speedy.coacade.uv.mx
  
  

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Copyright 1995-2014 David W. A. Bourne (david@boomer.org)