Back to the Top
Hello,
This is a reply to Won Young Lee's question about adhesive systems for
mucous membranes.
During my Ph.D. research (on buccal drug delivery) I made use of such a
system for studying drug administration at the site of the cheek, in pigs. I
used Oral Adhesive Bandage, from Squibb. It is on the market for wound
healing in the oral cavity, for humans. It is manufactured by Squibb
Institute for Medical Research, New Brunswick, New Jersey. While I was
working in Leiden, The Netherlands,I bought it from the distributor for
Squibb in the Netherlands.
I used this bandage to stick a small plastic application chamber to the
inside of the cheek, in pigs. Unfortunately, the animals did not like having
anything in their mouth against their will and after many trials I finally
decided to do the study using slightly sedated pigs. If you are using dogs
though, you might have more luck, they tolerate much more, as I found out in
later studies with mucoadhesive tablets in dogs.
I cound send you a copy of a paper about this bandage if you send me you fax
number, or you could look it up youself, a paper by I.W. Scopp in
J.Periodontol. 39 (1968) 16-20.
I hope this can help you. If you want some more information, do not hesitate
to contact me.
kind regards,
Janet Hoogstraate, Ph.D.
Astra Pain Control AB
Pharmaceutical and Analytical R&D
Oral Systems
15185 Sodertalje
Sweden
|
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@lists.ucdenver.edu with "Adhesive systems for mucous membranes" as the subject | Support PharmPK by considering my eBooks |
Copyright 1995-2014 David W. A. Bourne (david@boomer.org)