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>The following even more recent meta-analysis paper might be of some interest:
Ferriols-Lisart and Alos-Alminana. Effectiveness and safety of once-daily
aminoglycosides: a meta-analysis. Am J Health-Syst Pharm.1996; 53:1141-50.
They reached the same conclusion as almost everybody who use ODA in clinical
practice - this dosing method may be more effective and less toxic than the
traditional multiple-daily dosing method. However, there is still
insufficient data particularly in immunocompromised (e.g., neutropenic) pts.
I hope this is useful.
N. Anaizi, PhD RPh
Univ. of Rochester Med. Center.
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