PharmPK Discussion - Bayesian pharmacokinetics

• On 21 Jun 1996 at 14:44:24, Randy3658.-a-.aol.com sent the message
  

  
  Can anyone suggest some references which I can read which describe the basic
  foundational principles underlying bayesian pharmacokinetics?   I would
  especially like a few sources which just go over the basic principles without
  getting too technical.   I've heard that Bayes theorem represents some kind
  of statistical technique using population parameters or something.  I've seen
  it compared in studies and advertised in pharmacokinetic programs to
  "traditional" pharmacokinetic techniques but have never had a really good
  conception of what is represents or how to utilize it.  Any help would be
  greatly appreciated.
  
  Thanks
  Randy Kuiper, RPh.
  Great Falls, MT
  
  

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• On 21 Jun 1996 at 22:51:48, "Michael Burton" (michael.burton.-a-.DISPATCHER.NET.uokhsc.edu) sent the message
  

  
  There are several articles written on Bayesian theory relating to
  pharmacokinetics.
  
  Sheiner LB, Rosenberg B, Melmon KL.  Modelling of individual pharmacokinetics
  for computer-aided drug dosage.  Computers and biomedical research  1972; 5:
  441-459.  (One of the original articles)
  
  Sheiner LB, Beal SL, Rosenberg B, et al.  Forecasting individual
  pharmacokinetics.  Clinical Pharmacology and Therapeutics 1979; 26:  294-305.
  
  Sheiner LB, Rosenberg B, Marathe VV.  Estimation of population
  characteristics of pharmacokinetics parameters from routine clinical data.
  Journal of Pharmacokinetics and Biopharmaceutics  1977; 5: 445-79.
  
  Sheiner LB, Beal SL.  Bayesian individualization of pharmacokinetics:  Simple
  implementation and comparison with non-bayesian methods.  Journal of
  Pharmaceutical Sciences  1982; 71: 1344-8.
  
  Schumacher GE, Barr JT.  Bayesian approaches to pharmacokinetic decision
  making.  Clinical Pharmacy  1984; 3: 525-30.  A straightforward simple
  review.
  
  Vozeh S, Steimer JL.  Feedback control methods for drug dosage optimisation.
  Concepts, classification and clinical application.  Clinical Pharmacokinetics
   1985; 10:  457-476.
  
  I hope these references help.
  
  

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• On 24 Jun 1996 at 10:39:29, "Vladimir Piotrovskij" (VPIOTROV.at.JANBELC1.SSW.JNJ.COM) sent the message
  

  
       As the matter of fact, there is no Bayesian pharmacokinetics. There is
       a method of obtaining individual estimates of PK parameters from few
       measurements (not sufficient to get them in a standard way by fitting
       a model to these measurements) which is called Bayesian
       individualization. To apply it, you should know (i) the PK model, (ii)
       population averages of model parameters, (iii) inter-individual
       variability in these parameters, and (iv) residual (intra-individual)
       variability in your measurements not explained by inter-individual
       differences in PK parameters. Then, you need a nonlinear regression
       program which minimises an objective function of special form called
       Bayesian objective function.
  
       In addition to the references given by Michael Burton I would
       recommend several more recent publications:
  
       Proost, J.H. Adaptive control of drug dosage regimens using maximum a
       posteriori probability Bayesian fitting. Int J Clin Pharm
       Therapeutics, 1995, 33: 531-536.
  
       Wakefield, J. and Racine-Poon, A. An application of Bayesian
       population pharmacokinetic/ pharmacodynamic models to dose
       recommendation. Stat Med. 1995; 14(9-10):971-986.
  
       Tanigawara, Y.; Yano, I.; Kawakatsu, K.; Nishimura, K.; Yasuhara, M.,
       and Hori, R. Predictive performance of the Bayesian analysis - effects
       of blood sampling time, population parameters, and pharmacostatistical
       model. Journal of Pharmacokinetics and Biopharmaceutics. 1994;
       22(1):59-71.
  
       El-Desoky, E.; Meinshausen, J.; Buhl, K.; Engel, G.; Haringskaim, A.;
       Drewelow, B., and Klotz, U. Generation of pharmacokinetic data during
       routine therapeutic drug monitoring: Bayesian approach vs
       pharmacokinetic studies. Ther. Drug. Monit. 1993; 15(4):281-288.
  
       You can find a lot of references to more specific publications in
       these papers.
  
       --------
       Vladimir Piotrovskij, Ph.D.           Fax: +32-14-603768
       Janssen Research Foundation           Email: vpiotrov.aaa.janbe.jnj.com
       Clinical Pharmacokinetics
       B-2340 Beerse
       Belgium
  
  from: "Vladimir Piotrovskij" 
  

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• On 25 Jun 1996 at 12:10:48, Steven Ebert (sebert.-at-.facstaff.wisc.edu) sent the message
  

  
  Perhaps a statement on Bayesian methodology of pharmacokinetic analysis and
  its cost-utility in a clinical setting would be a useful topic, vis a vis
  our prevoius discussions on consensus statements.
  
  

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