PharmPK Discussion - Chiou Method

• On 19 Nov 1996 at 17:08:49, Cathy Heyneman (cathy.-at-.otc.isu.edu) sent the message
  

  
  Hello all!
  
  I do grading for a pharmacokinetics course.  One of our students has asked
  me about the Chiou (not sure of the spelling here) relationship used for
  determining clearance of dig and procainamide.  They'd like to know if
  there's a paper or book out there that discusses proper usage of this
  equation.  I've looked through all my resources and come up empty.
  
  Any input from you folks would be greatly appreciated.
  
  Thanks in advance!
  
  Cath
  
  Catherine Heyneman, Pharm.D.    Phone:    (208) 236-2743
  ISU College of Pharmacy         FAX:      (208) 236-4305
  Pocatello, ID 83209             E-Mail: cathy.-a-.elixir.isu.edu
  
  

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• On 20 Nov 1996 at 15:59:29, Varun Garg (VARUNG.-at-.OTSUKA.OAPI.COM) sent the message
  

  
  I think the reference you are seeking is:
  Chiou WL, et al.  Method for the rapid estimation of total body drug
  clearance and adjustment of dosage regimens in patients during
  constant-rate intravenous infusion.  J. Pharmacok. Biopharm. 6:135-151,
  1978.
  
  Hope that helps,
  Varun Garg
  Otsuka America Pharmaceutical, Inc.
  
  

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• On 25 Nov 1996 at 10:09:09, "Michael Burton" (michael.burton.-a-.DISPATCHER.NET.uokhsc.edu) sent the message
  

  
  The reference for the Chiou paper is:
  
  Chiou WL, et al.  Method for rapid estimation of the total body clearance and
  adjustment of dosage regimens in patients during a constant-rate intravenous
  infusion.  J Pharmacokinet Biopharm.  1978; 6: 135.
  
  This method can be used for any drug that is given by continuous infusion.
  All that is needed to derive a clearance value is the rate of infusion, a
  population volume of distribution (L/kg*whichever weight is appropriate for
  the drug (IBW, DW, TBW)), and two serum concentrations drawn after the
  beginning of the continuous infusion perferably 1-2 half-lives apart, and the
  time difference between those concentrations.
  
  The equation is:
  
  CL= (2Ro/C1+C2) + ((2Vd(C1-C2)/(C1+C2)(t2-t1)
  
  Where Ro = infusion rate in mg/h
             Vd = population Volume of distribution in L
             C1 = first serum concentration drawn after beginning infusion
             C2 = second serum concentration drawn after beginning infusion
             t1 = time of C1
             t2 = time of C2.
  
  Although this equation is commonly used with theophylline, it can be used
  with intravenous procainamide.  I don't believe it has an application with
  digoxin since it is administered either orally or IV push.
  
  

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