PharmPK Discussion - Drug interaction study to role of Cytochrome P-450 2D6

• On 18 Dec 1996 at 11:00:43, Prasad Tata (Prasadt.-a-.OTSUKA.OAPI.COM) sent the message
  

  
  We all know for studying cytochrome P-450 2D6 role in drug metabolism
  it is customary to study Drug-Quinidine interaction. Due to fluorescent
  interference  of quinidine with the study drug,  I am considering to use
  Ajmalicine (reported Ki = 0.014) or prodipine (Ki = 0.0048). Can
  somebody share their clinical or analytical experiences with me.
  
  Thank you in advance for your input.
  
  Prasad Tata, Ph.D.
  
  

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• On 19 Dec 1996 at 11:00:15, Krsjones.-at-.aol.com sent the message
  

  
  In response to the 2D6 question- A lot of work has been done using
  dextromethorphan as a marker for 2D6.  Perhaps that could be an alternative
  agent you could use.
  
  Kristen Jones, PharmD, BCPS
  Assistant Professor
  Campbell University
  Buies Creek, NC 27506
  
  

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• On 23 Dec 1996 at 14:11:13, rajesh krishna (rkrishna.-at-.unixg.ubc.ca) sent the message
  

  
  Prasad:
  
  There is a paper in the Journal of Medicinal Chemistry which appeared in
  1993 (Vol.36, issue 9, pages 1136-45) entitled "development of a
  pharmacophore for inhibition of human liver cytochrome P450 2D6:
  molecular modeling and inhibition studies" by Strobl GR et al, that you
  may find informative (I know this does not answer your question directly!).
  
  -Rajesh
  
  

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