PharmPK Discussion - Indinavir solubility

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On 13 Dec 1996 at 10:50:44, "Faruq H Noormohamed" (f.noormohamed.at.s1.cxwms.ac.uk) sent the message


Indinavir (Crixivan) has poor solubility in urine at neutral PH  or so I
have been informed.  Does any one have any details on the solubility
characteristics on this drug and how the solubility can be enhanced to
prevent crystaluria?

Any answers will be greatly appreciated
Faruq Noormohamed
Faruq H Noormohamed
Department of Therapeutics
Chelsea andWestminster Hospital
369 Fulham Road
LONDON
SW10 9NH

Tel +44 (0)181 746 8141
Fax +44 (0)181 746 8887
email f.noormohamed.at.cxwms.ac.uk

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