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Dear all
Does anyone have any information on the solubility of the
antiinflammatory drug, nimesulide? We are beginning to examine the kinetics
and effects of this compound in our chronically instrumented sheep model and
would like to infuse the drug intravenously over several hours. The
compound is a sulfonamide and appears to be soluble in water at a pH > 8.3.
I have concerns about a prolonged infusion at this pH so would appreciate
any additional information that may allow us to prepare a more physiological
solution (ie., pH ~7.4).
Thank you for your assistance with this problem.
Sincerely,
Wayne Riggs, Ph.D.
Faculty of Pharmaceutical Sciences
The University of British Columbia
Vancouver, B.C. Canada
(604)-822-2061
Back to the Top
Dear all
Does anyone have any information on the solubility of the
antiinflammatory drug, nimesulide? We are beginning to examine the
kinetics
and effects of this compound in our chronically instrumented sheep model
and
would like to infuse the drug intravenously over several hours. The
compound is a sulfonamide and appears to be soluble in water at a pH >
8.3.
I have concerns about a prolonged infusion at this pH so would appreciate
any additional information that may allow us to prepare a more
physiological
solution (ie., pH ~7.4).
Thank you for your assistance with this problem.
Sincerely,
Wayne Riggs, Ph.D.
Faculty of Pharmaceutical Sciences
The University of British Columbia
Vancouver, B.C. Canada
(604)-822-2061
You could try to solibilize it with glycine or meglumine (1:1 molar) at
lower pH's.
D.J. Touw
Academic Hospital Vrije Universiteit
Amsterdam, The Netherlands
dj.touw.-a-.azvu.nl
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