PharmPK Discussion - Oleic acid & Lymph.

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On 7 Feb 1996 at 11:28:28, KJ CROWLEY (K.J.Crowley.-a-.bradford.ac.uk) sent the message


Dear all.
I am a research student at the University of Bradford (UK), and intend to
investigate how oleic acid alters the bioavailability of drugs that have
a high hepatic first pass metabolism, e.g. propranolol, metoprolol,
felodipine. I am in the pharmaceutical technology dept., so am
concentrating on the formulation aspect of drug delivery.

Work with propranolol and oleic acid suggests increased lymphatic
transport of the drug (e.g.Barnwell, Int J Pharm 1992) but considering
propranolols' moderate lipophilicity (logP o/w = 3) this seems doubtful.
Any thoughts?

I would be grateful for any comments, advice, constructive criticism
concerning oleic acids possible effects on bioavailability. Please get in
touch.......I'm only a keyboard and a few thousands kilometers of cable away!

Thanks, Kieran.

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On 12 Feb 1996 at 11:25:19, JPaul78008.-at-.aol.com sent the message
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What was the evidence presented in that article for lymphatic transport ?
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On 13 Feb 1996 at 09:58:08, LATHIAC (lathiac.-at-.aa.wl.com) sent the message


>What was the evidence presented in that article for lymphatic transport ?

Lymphatic cannulation.

Chetan

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