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For Once-daily aminoglycoside dosing:
Two references are:
Nicolau,DP, Freeman,CD, Belleveau,PB, et al. Experience with a
Once-Daily Aminoglycoside Program Administered to 2,184 Adult Patients.
Antimicrobial Agents and Chemotherapy. 1995;39(3):650-655.
Gilbert, DN. Once-Daily aminoglycoside therapy. Antimicrobial Agents
and Chemotherapy. 1991;35(3):
399-405.
The dose given is usually 6 to7mg/kg for Gentamicin or Tobramycin, and the
frequency is adjusted based on a random level as shown in the nomogram in
Nicolau's paper. I am not aware of a paper describing once daily dosing in
pediatrics, and we use conventional dosing (adjusted by levels) for patients
with renal failure or deep tissue infections (osteo, or endocarditis).
NameWithheld
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On the Once-daily aminoglycoside story
The blokes at Clinical Pharmacology in Christchurch (NZ) have been the
southern hemisphere players in this game fro some time.
This team have published some clear guidelines and a suggested approach
Evan Begg, Murray Barclay, Steve Dufful. A suggested approach to once-daily
aminoglycoside dosing
Brit J Clin Pharmacol 1995: 39; 605-609
Barclay, Dufful, Begg & Buttimore. Experience of once-daily aminoglycoside
dosing using a traget area under the concentration-yimr curve.
Aust NZ J Med 1995; 25: 230-235
There has also been a meta-analysis looking at some of the published data
Galloe et al. Aminoglycosides: single or multiple daily dosing? A
meta-analysis on efficacy and safety
Eur J Clin Pharmacol 1995; 48: 39-43
I hope this helps.
Also you might like to contact Stevet Dufful (sdufful.-at-.chmeds.ac.nz)
Andrew McLachlan
Dept Pharmacy, Uni of Sydney
NSW 2006 Australia
Phone -61-2-351-4452
Fax -61-2-351-4447
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