PharmPK Discussion - Some questions about Cardizem!

• On 25 Sep 1996 at 10:51:27, TTANABE (tn1.-at-.ms10.hinet.net) sent the message
  

  
  I am a pharmacist in Taiwan.
  There is a problem of Cardizem SR (Diltiazem 90mg capsule) approval by FDA
  that the drug is recommanded to q.d. administration, but the conventional
  formulation of diltiazem is suggested for a daily dose 240~360mg to treat
  angina or hypertension patients in PDR 1996. So We doult the plasm serum
  level of Cardizem SR capsule 90mg seens to be lower for therapeutic use. Is
  it true of the above doult?
  
  Would you kindly inform me that where I can get the plasma concentration in
  steady-state of Cardizem SR capsule 90mg.
  
  Thank you for your cooperations!
  
  Nick m. Wang
  tn1.aaa.ms10.hinet.net
  
  

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• On 26 Sep 1996 at 10:32:30, BERTRX.at.aol.com sent the message
  

  
  Cardizem comes in two sustained released formulations.
  
  The SR formulation is normally dosed twice daily.
  
  The CD formulation is normally dosed once daily.
  
  

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• On 27 Sep 1996 at 10:38:44, Robert Aucoin (mraucoin.-at-.linknet.net) sent the message
  

  
  At 10:32 AM 9/26/96 -0500, you wrote:
  >PharmPK - Discussions about Pharmacokinetics
  > Pharmacodynamics and related topics
  >
  >Cardizem comes in two sustained released formulations.
  >
  >The SR formulation is normally dosed twice daily.
  >
  >The CD formulation is normally dosed once daily.
  >
  There is also a Clinical Pharmacology web site that give pretty good
  information.
     Their address is "http://www.gsm.com/resources/cponline"
  
  Good luck...   Robert
  Robert G. Aucoin RPh
  Peds Clinical Pharmacist
  OLOL RMC
  Baton Rouge, LA
  mraucoin.aaa.linknet.net
  
  

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• On 30 Sep 1996 at 10:20:49, eddyjh.-a-.moose.ncia.net (John Eddy) sent the message
  

  
  >PharmPK - Discussions about Pharmacokinetics
  > The SR formulation is not intended for daily use; rather it is to be given
  every 8 t0 12 hours.  The CD preparation is given once a day.  I think your
  confusion may be over the suffix SR and CD.  if you have questions refer to
  the package insert or call the manufacturer of Cardizem.  Hope this helps.>
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