PharmPK Discussion - t1/2 of aminoglycosides

• On 5 Nov 1996 at 11:38:08, "Randy Trinkle" (rtrinkle.at.pris.bc.ca) sent the message
  

  
  ill ICU patients, women with postpartum endometritis, the elderly,
  neutropenic adults?  In some of these groups, particularly the
  ventilated, critically-ill ICU patient, there is high interpatient
  variability.
  
  Konrad F, Wagner R, Neumeister B, Rommel H, Georgieff M.
  Studies on drug monitoring in thrice and once daily treatment
  with aminoglycosides. Intensive Care Med 1993;19:215-250.
  
  van Dalen R, Vree TB. Pharmacokinetics of antibiotics in
  critically ill patients. Intensive Care Med 1990;16(Suppl 3):
  S235-S238.
  
  del Priore G, Jackson-Stone M, Shim EK, Garfinkel J, Eichman MA,
  Frederiksen MC. A comparison of once-daily and 8-hour gentamicin
  dosing in the treatment of postpartum endometritis. Obstet Gynecol
  1996;87:994-1000.
  
  Vanhaeverbeek M, Siska G, Herchuelz A. Pharmacokinetics of once-
  daily amikacin in elderly patients. J Antimicrob Chemother 1993;31:
  185-187.
  
  MacGowan AP, Bedford KA, Blundell E, Brown NM, Habib F,
  Hows J, Kirkpatrick B, Korner RJ, Slade RR, White LO, Reeves
  DS. The pharmacokinetics of once daily gentamicin in neutropenic
  adults with haematological malignancy.
  
  ********************************
  Randy Trinkle, BScPharm, BA
  Dept. of Pharmacy
  Dawson Creek & District Hospital
  Dawson Creek, BC
  mailto://rtrinkle.at.pris.bc.ca
  ********************************
  
  Every now and then when your life gets complicated...
                                                 HST
  from: "Randy Trinkle" 
  

  Back to the Top

Copyright 1995-2014 David W. A. Bourne (david@boomer.org)