PharmPK Discussion - ANOVA for comparison of bioavailabilities

PharmPK Discussion List Archive Index page

On 11 Dec 1997 at 14:04:56, Philippe.Maincent.aaa.pharma.u-nancy.fr (Philippe MAINCENT) sent the message


Hi,

I think it is possible to use Anova for the purpose of comparison of AUC
(after log transformation) and MRT and MAT as well. Could that be confirmed
and does anyone knows a textbook or an article which describes it?

Thanks

P. Maincent

Professor P. Maincent
Laboratoire de Pharmacie Galenique

Back to the Top

On 18 Dec 1997 at 10:37:12, "Piotrovskij, Vladimir" (vpiotrov.-a-.janbe.jnj.com) sent the message


     You can use ANOVA to compare everything. The major problem is that
AUC
     itself as calculated by trapezoidal summation (a common approach in

     bioavailability/bioequivalence studies) is a biased estimate of the

     true AUC. Since MRT and MAT include a higher moment, they are even
     more biased. Thus, any conclusion you get after applying ANOVA is
     doubtful.

     Vladimir
     vpiotrov.at.janbe.jnj.com

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "ANOVA for comparison of bioavailabilities" as the subject

PharmPK Discussion List Archive Index page