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There is nothing in the ACB Assayfinder
The UK NEQAS for Antibiotic Assays is provided by:
Department of Microbiology, Southmead Health Services NHS Trust
Bristol BS10 5NB, UK.
Tel INT+UK+117 9595653 Fax INT+UK+117 9593217
http://www.ukneqasaa.win-uk.net
from: Dr Les White
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To: Dr. Les White
If you need a reference read
Juma et al. Cancer Chemother. Pharmacol. 1: 229, 1978
or
Teicher B.A. et al. Cancer Chemother. Pharmacol. 38: 553-560, 1996
If you need a Lab that can do the analysis for you try
Beverley Teicher at the Dana-Farber Cancer Institute, 44 Binney St., Boston
MA 02115 Fax (617) 632-2411
Good Luck
Anup Zutshi (zutshi.-at-.battelle.org)
PharmPK - Discussions about Pharmacokinetics
Pharmacodynamics and related topics
There is nothing in the ACB Assayfinder
The UK NEQAS for Antibiotic Assays is provided by:
Department of Microbiology, Southmead Health Services NHS Trust
Bristol BS10 5NB, UK.
Tel INT+UK+117 9595653 Fax INT+UK+117 9593217
http://www.ukneqasaa.win-uk.net
from: Dr Les White
Also see: http://www.cpb.uokhsc.edu/pkin/pkin.html
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From: Andrew Sutton
Organization: Guildford Clinical Pharmacology
MIME-Version: 1.0
To: PharmPK.-a-.pharm.cpb.uokhsc.edu
Subject: Re: pharmpk Cyclophosphamide
Dear Les,
Why not try Henry Chrystyn at Bradford. He has done some work with
cyclophosphamide
enantiomers.
Also try Dr Yule at The University of Newcastle (Brit J Clin Pharmacol
1996, 41, 13-19). Also
Steve Soldin at University of Toronto?
All the best,
Graham
-
Date: Thu, 10 Jul 1997 08:59:22 -0400 (EDT)
From: TIANLING CHEN
To: pharmpk
Subject: Re:pharmpk Cyclophosphamide (fwd)
MIME-Version: 1.0
There are many published methods for the determination of
cyclophosphamide and its metabolite, 4-OH cyclophosphamide concentrations
in biological fluids. I list a few citations for your reference as follows:
T-L. Chen, J.L. Passos-Coelho, D.A. Noe, M.J. Kennedy, K.C.
Black, O.M. Colvin and L.B. Grochow: Nonlinear pharmacokinetics of
cyclophosphamide in patients with metastatic breast cancer receiving
high-dose chemotherapy followed by autologous bone marrow
transplantation. Cancer Research 55, 810-816 (1995).
L.W. Anderson, S.M. Luderman, O.M. Colvin, L.B. Grochow, J.M.
Strong: Quatitation of 4-hydroxycyclophosphamide/aldophosphamide in
whole blood. J. Chromatog. B. 667, 247-257 (1995).
L.W. Anderson, T.-L. Chen, O.M. Colvin, L.B. Grochow, J.M.
Collins, M.J. Kennedy, J.M. Strong: Cyclophosphamide and
4-hydroxycyclophosphamide/aldophosphamide kinetics in patients receiving
high-dose cyclophosphamide chemotherapy. Clin. Cancer Res. 2, 1481-1487,
(1996).
J.T. Slattery, T.F., Kalhorn, G.B. McDonald, K. Lambert, C.D.,
Buckner, W.I. Bensinger, C. Anasetti, F.R. Appelbaum.
Conditioning regimen-dependent disposition of cyclophosphamide and
hydroxycyclophosphamide in human marrow transplantation patients.
J. Clin. Oncol. 5, 1484-1494, (1996).
K.K. Chan, P.S. Hong, K. Tutsch, and D.L. Trump: Clinical
pharmacokinetics of cyclophosphamide and metabolites with and without
SR-2508. Cancer Res. 54, 6421- 6429 (1994).
Please let me know if you need more information.
Tianling (tlc.at.welchlink.welch.jhu.edu)
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>-----Original Message-----
>[Tata Prasad] Good account of analytical methods were documented in one of
>the issues of Analytical Profiles of Drug Substances Ed. Klaus Forey (I am
>not too sure of the volume number)
>
>Word of caution never heat the plasma samples above 35C as Cyclophosphamide
>degrades to completeness.
>
>Regards,
>
>Prasad
>Date: Thu, 10 Jul 1997 08:59:22 -0400 (EDT)
>From: TIANLING CHEN
>To: pharmpk
>Subject: Re:pharmpk Cyclophosphamide (fwd)
>MIME-Version: 1.0
>
>There are many published methods for the determination of
>cyclophosphamide and its metabolite, 4-OH cyclophosphamide concentrations
>in biological fluids. I list a few citations for your reference as follows:
>
>T-L. Chen, J.L. Passos-Coelho, D.A. Noe, M.J. Kennedy, K.C.
>Black, O.M. Colvin and L.B. Grochow: Nonlinear pharmacokinetics of
>cyclophosphamide in patients with metastatic breast cancer receiving
>high-dose chemotherapy followed by autologous bone marrow
>transplantation. Cancer Research 55, 810-816 (1995).
>
>L.W. Anderson, S.M. Luderman, O.M. Colvin, L.B. Grochow, J.M.
>Strong: Quatitation of 4-hydroxycyclophosphamide/aldophosphamide in
>whole blood. J. Chromatog. B. 667, 247-257 (1995).
>
>L.W. Anderson, T.-L. Chen, O.M. Colvin, L.B. Grochow, J.M.
>Collins, M.J. Kennedy, J.M. Strong: Cyclophosphamide and
>4-hydroxycyclophosphamide/aldophosphamide kinetics in patients receiving
>high-dose cyclophosphamide chemotherapy. Clin. Cancer Res. 2, 1481-1487,
>(1996).
>
>J.T. Slattery, T.F., Kalhorn, G.B. McDonald, K. Lambert, C.D.,
>Buckner, W.I. Bensinger, C. Anasetti, F.R. Appelbaum.
>Conditioning regimen-dependent disposition of cyclophosphamide and
>hydroxycyclophosphamide in human marrow transplantation patients.
>J. Clin. Oncol. 5, 1484-1494, (1996).
>
>K.K. Chan, P.S. Hong, K. Tutsch, and D.L. Trump: Clinical
>pharmacokinetics of cyclophosphamide and metabolites with and without
>SR-2508. Cancer Res. 54, 6421- 6429 (1994).
>
>Please let me know if you need more information.
>
>Tianling (tlc.aaa.welchlink.welch.jhu.edu)
>
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)