PharmPK Discussion - High throughput PK

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On 10 Sep 1997 at 10:47:38, "Vakily, Majid" (MAJID.VAKILY.aaa.roche.com) sent the message


Hi,

In order to increase screening efficiency early in drug discovery,
using a cocktail dosing solutions containing a certain number of drug
molecules (~5) seems to be an attractive approach for PK studies.
Drug interaction seems one of the major concerns. How one can minimize
drug interaction and obtain reasonably useful information from
cocktail design?

Are there some studies published?

What kind of criteria should be employed in selection of drugs which
are going to be formulated as a cocktail dosing solution? Analog
series vs. heterogeneous group of molecules

Your input in this discussion appreciated

Regards

Majid

Majid Vakily Ph.D.

Principal Research Scientist
Hoffmann La Roche
Drug Metabolism and Pharmacokinetics/Discovery
Room No 1545
Phone: (201) 235-2251
Fax: (201) 235-7010
Internet e-mail: majid.vakily.-at-.Roche.com

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On 11 Sep 1997 at 09:47:20, "Michael Mayersohn, Ph.D." (mayerson.aaa.Pharmacy.Arizona.EDU) sent the message
```
MAJID
 There is only one study that I am aware of: Berman et al.,
J. Medicinal Chem., 40; 827-829 (1997).
Michael Mayersohn
```
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On 11 Sep 1997 at 09:47:53, "P.H. van der Graaf" (vdgraaf.at.CHEM.LeidenUniv.nl) sent the message


You might be interested in the following two papers:

Berman, J. et al. (1997)  Simultaneous pharmacokinetic screening of a
mixture of compounds in the dog using API LC/MS/MS analysis for increased
throughput.  J. Med. Chem. 40: 827-829.

Olah, T.V. et al. (1997)  The simultaneous determination of mixtures of drug
candidates by liquid chromatography atmospheric pressure chemical ionization
mass spectrometry as an in vivo drug screening procedure.  Rapid Commun.
Mass Spectrom. 11:17-23.

Regards,

Piet H. VAN DER GRAAF.

DR P.H. VAN DER GRAAF
Leiden/Amsterdam Center for Drug Research
Department of Pharmacology
P.O. Box 9503
2300RA  LEIDEN
The Netherlands
tel ++-31-71-5276214/1
fax ++-31-71-5276292
email: vdgraaf.aaa.lacdr.leidenuniv.nl

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