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I am writing a modelling program for the Psion computer. I have been
unable to find complete 3 compartment data on the following drugs - does
anyone have the data or know where to find it?
Ketamine
Alfentanil
Fentanyl
Obviously I need the compartment volumes, v1, v2, v3, and the
coefficients k10, k12, k21, k31, k13. Failing that Clearances and
volumes should be enough to calculate the coefficients.
Help. Please.
--
Dr Simon Ashworth - HREF="http://www.users.dircon.co.uk/~rosebud/index.htm">visit my home
page
Dept Anaesthetics, Hammersmith Hospitals NHS Trust, LONDON
SnailMail: 136 Sinclair rd, LONDON W14 ONL, UK
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To: Dr. Simon Ashworth
Fentanyl
Olkkola K.T. et al. in Clinical Pharmacokinet. 28: 385-404, 1995
Ketamine
White P.F. et al. in Br. J. of Anaesth. 57: 197-203, 1985
A review article published for the above two drugs before these dates can
help
you identify and cross-reference. This article is
Ghoneim M.M. and Korttila K. in Clinical Pharmacokinetics 2: 344-372, 1977
Alfentanyl
Bodenham A and Park G.R. in Clinical Pharmacokinetics 15: 216-226, 1988
Good Luck
A. Zutshi (Zutshi.-a-.battelle.org)
PharmPK - Discussions about Pharmacokinetics
Pharmacodynamics and related topics
I am writing a modelling program for the Psion computer. I have been
unable to find complete 3 compartment data on the following drugs - does
anyone have the data or know where to find it?
Ketamine
Alfentanil
Fentanyl
Obviously I need the compartment volumes, v1, v2, v3, and the
coefficients k10, k12, k21, k31, k13. Failing that Clearances and
volumes should be enough to calculate the coefficients.
Help. Please.
--
Dr Simon Ashworth - HREF="http://www.users.dircon.co.uk/~rosebud/index.htm">visit my home
page
Dept Anaesthetics, Hammersmith Hospitals NHS Trust, LONDON
SnailMail: 136 Sinclair rd, LONDON W14 ONL, UK
rosebud was a mistake - honestly I was just testing - I assumed someone
would already have used Citizen Kane!
Also see: http://www.cpb.uokhsc.edu/pkin/pkin.html
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>I am writing a modelling program for the Psion computer. I have been
>unable to find complete 3 compartment data on the following drugs - does
>anyone have the data or know where to find it?
>Ketamine
>Alfentanil
>Fentanyl
>
>Obviously I need the compartment volumes, v1, v2, v3, and the
>coefficients k10, k12, k21, k31, k13. Failing that Clearances and
>volumes should be enough to calculate the coefficients.
>Help. Please.
>--
>Dr Simon Ashworth
Here are references that I got in Dr. J.F.Coetzee's Simmulation + CACI
Program, STELPUMP:
Ketamine: Bomino et al. Clin Pharmacol Ther 1984; 36: 645-653
Alfentanyl: Maitre et al. Anesthesiology 1987; 66: 3-12
Scott JC, Stanski DR. J Pharm Exp Ther 1987; 240:159-166
Fentanyl: Shafer et al Anesthesiology 1988; 69: A460
Scott et al. J Pharm Exp Ther 1987; 240:159-166 (keo from article?)
Any other/newer references?
() Stefan Harms .-a-. "Squirrel's End"
/\/
() Stefan_Harms.-a-.mbnet.mb.ca
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From: cawello.-at-.schwarzpharma.com
Date: Thu, 10 Jul 1997 09:12:00 +0100
Sender: cawello.at.schwarzpharma.com
Reply-To:
Organization: Schwarz Pharma AG
To: pharmpk.aaa.pharm.cpb.uokhsc.edu
Subject: re: Ketamine pharmacokinetics
Importance: Normal
MIME-Version: 1.0
Form: Reply
Text: (8 lines follow)
According to fentanyl you will find first informations on pharmacokinetic
rate constants in this articles:
Shofer SL; Varvel JR, Anesthesiology 1991; 74: 53-63
Lemmens HJM; et al., Clin Pharmacol Ther 1994; 56: 261-71
Willi Cawello PhD, Schwarz Pharma company
D40789 Monheim am Rhein, Germany
-
Date: 10 Jul 1997 08:29:08 EST
From: "Vladimir Piotrovskij"
Subject: Re: Ketamine pharmacokinetics
To: PharmPK.-a-.pharm.cpb.uokhsc.edu
Comment: MEMO 07/10/97 08:26:00
The following references may be useful:
1. Youngs EJ. Shafer SL.
Pharmacokinetic parameters relevant to recovery from opioids
Anesthesiology. 81(4):833-42, 1994
2. Lemmens HJ. Dyck JB. Shafer SL. Stanski DR.
Pharmacokinetic-pharmacodynamic modeling in drug development:
application to the investigational opioid trefentanil.
Clinical Pharmacology & Therapeutics. 56(3):261-71, 1994
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