PharmPK Discussion - Netilmicin pharmacokinetics in neonates

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On 21 Oct 1997 at 10:11:52, "harry chiu" (chiu9598.at.hkstar.com) sent the message


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I am deciding to perform a clinical project in evaluating the netilmicin
pharmacokinetics parameters on Chinese neonates.  Does anyone have the data
or know where to find any relevent information regarding the design of the
study and any relevant references that I can refer to?

Harry Chiu
Clinical Pharmacist
Hong Kong

my email address: chiu9598.-a-.hkstar.com

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On 23 Oct 1997 at 09:44:43, David_Bourne (david.-at-.pharm.cpb.uokhsc.edu) sent the message

[Another popular question - db]

Date: Tue, 21 Oct 1997 19:10:20 -0500
From: "Dr. Gamal Hussein" 
Reply-To: GHussein-clinPharm.-at-.worldnet.att.net
MIME-Version: 1.0
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
Subject: Re: Netilmicin pharmacokinetics in neonates

You may contact Dr. Roger Jelliffe, he has done excellent work in this
area. His coputer program will be very helpful. I have attached his web
site to this message. His info is as follow:
Phone (213)342-1300, Fax (213)342-1302
email=jelliffe.-at-.hsc.usc.edu
It is    http://www.usc.edu/hsc/lab_apk/

=======================Gamal Hussein, Pharm.D. at http://www.ClinPharmInt.com/Hussein.htm
    Associate Professor of Pharmacy
	Northeast Louisiana University-Pharmacy School
    Associate Professor of Neurology
	Louisiana State University-Medical School
    Clinical Coordinator of Clinical Pharmacy/Pharmacology Program
	The Medical Center of Louisiana at New Orleans
email=PYHussein.at.Alpha.NLU.edu

--

From: Alison Thomson 
Organization: Glasgow University
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
Date: Wed, 22 Oct 1997 18:01:24 GMT
MIME-Version: 1.0
Subject: Re: Netilmicin pharmacokinetics in neonates
Reply-to: a.h.thomson.-at-.clinmed.gla.ac.uk
Priority: normal

See Fattinger et al, Clinical Pharmacology & Therapeutics 1991
vol 50 p 55-65
 Darwish et al, Biopharmaceutics & Drug Disposition 1992
vol 13: p105 -118
Kuhn et al European Journal of Clinical Pharmacology 1986 vol 29
pages 635 - 637
Granati et al The Journal of Pediatrics 1985 vol 106 p 664-669

Alison Thomson

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Date: Wed, 22 Oct 1997 19:06:23 -0600 (CST)
Date-warning: Date header was inserted by CCTR.UMKC.EDU
From: sri melethil 
Subject: Re: Netilmicin pharmacokinetics (PK)in neonates
X-Sender: smelethil.-at-.cctr.umkc.edu
To: PharmPK.-at-.pharm.cpb.uokhsc.edu
Cc: smelethil.aaa.CCTR.UMKC.EDU
MIME-version: 1.0

Dear Harry:

Netilmicin (N) is like gentamicin and tobramycin with respect to its PK
properties.
Therefore renal function will be an important factor.  The recommended dose
(Goodman and Gilman, 9th Edition, page 1116) is 4 to 6.5 mg/kg per day in 2
divided doses.  by infusion; t1/2 of N can be as long as 37 hrs in neonates
(ibid, page 1765) Briefly, the following (preliminary) protocol is
recommended:

Administer the drug by infusion (3 mg/kg) over 1 hr, draw blood samples at
0.25,0.5, 2, 4, 6, 8,  12, 24, 36, 48 (post infusion)  in 10-12 neonates
whose renal function (creatinine clearance) is known.

Determine plasma concentrations of the drug.

From the post-infusion data, you should be able to determine the PK
parameters (such as t1/2, Vd, clearance).

Correlation analysis between PK parameters and renal function should be
useful in preparing nomogram for drug dosing.

Please contact me directly if I can be of further assistance.

Sincerely,

Sri

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