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Can someone give me info about the publisher of the new edition of the
Gabrielsson and Weiner book?
Thanks
Gary L. Elfring
from: GELFRING.-at-.am.pnu.com
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This new and expanded edition differs substantially from the first
edition in that pharmacokinetic and pharmacodynamic theory as well as
modeling concepts are expanded. Detailed sections on NCA, non-linear
kinetics (capacity, time, flow, and binding), turnover concepts,
pulsative functions, push-and-pull and precursor models, binding- and
displacement models, toxicokinetic models and determination of initial
parameter estimates for complex models are included. PART ONE of the
text is a basic introduction to pharmacokinetic and pharmacodynamic
modeling principles and can be understood by scientists with very little
formal training in this area. Complex mathematics are minimized.
Extensive graphical presentations accompany the theory. This enables the
scientist to conceptualize the underlying principles, such as clearance,
potency, tolerance weighting, and search algorithms. Issues on program
validation are also discussed. PART TWO is aimed to illustrate the
application of the concepts to specific modeling situations commonly
encountered at the drug industry and in research labs. Several new
exciting data sets on tolerance-rebound, dose-response-time models,
bacterial growth model, turnover, non-linear kinetics, oscillating input
functions, and toxicokinetics are also solved and discussed in this
section. The book bridges the gap between standard texts in
pharmacokinetics, pharmacology and numerical analysis, and provides
unique insight into the field of pharmacometrics in an easy to
understand manner.
* Substantially expanded concepts sections (kinetics, dynamics,
modeling)
* Increased graphical presentation of concepts and data
* State-of-the-art applications section
Availability:
The book + all example files on a diskette is available from the Swedish
Pharmaceutical Press (FAX +46-(0)8-14 95 80) or D. Weiner, SCI, Inc.
(FAX 919-859-6871, phone: 919-859-6868 or E-mail:
75450.3171.at.compuserve.com) for USD 160.
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)