Back to the Top
Partition coefficients (PCs) can vary widely for both tissue:air
values as well as tissue:blood. Here's my list of articles detailing
reported and how to predict PCs. How does one handle the large
disparages in values?
Poulin P and Kannan K "A biologically-based algorithm for predicting
human tissue:blood partition coefficeints of organic chemicals" -
sorry this was faxed and the citation was cut off.
Brit J of Ind Med 46:321-328, 1989.
Toxicol and Industrial Health 11(5):511-22, 1995.
Fund and Appl Toxicol 20 265-72, 1993.
Fund and Appl Toxicol 136 131-37, 1996.
J of Parmaceutical Sciences 72(10)1103-27, 1983.
Tox and Appl Parm 86 341-52, 1986.
Tox and Appl Parm 136, 126-30 1996.
I'm especially interested in the following chemicals:
Toluene, p- and o-xylene, ethylbenzene, hexane, decane,
1,1,1-trichloroethane, TCE, dichloromethane.
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (firstname.lastname@example.org)