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I have a question regarding the effects of prednisolone on the
pharmacokinetiks of other drugs.
We have seen a reduced oral clearance of a steroidal compound after
co-administration with prednisolon. This reduction seems to persist for at
least two weeks after discontinuation of prednisolone therapy. This seems
strange since the half life of prednisolon is 2-3 hours and the anti
inflamatory effect only last for 20-30 hours.
I have seen several papers describing the induction of prednisolone
metabolism by other compounds but I have not been able to find anything
regarding the effect of prednisolone on the PK of other drugs.
Any suggestions that could help solving this problem is greatly appreciated.
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