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Vladimir is not strictly correct about the estimation of AUMC,
although the combination rule may not be that bad. The reader is
referred to the paper by Robert Purves (J.P.B. vol. 20, 211-226
(1992)) and particularly the note by Adrian Dunne (J.P.B. vol. 17,
131-137 (1989)). Purves later went to look at the problem of
extrapolation for AUMC determination (J.P.B. vol. 20, 501-510 (1992)).
Leon Aarons
___________
Leon Aarons
School of Pharmacy and Pharmaceutical Sciences
University of Manchester
Manchester, M13 9PL, U.K.
tel +44-161-275-2357
fax +44-161-275-2396
email l.aarons.-at-.man.ac.uk
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Leon,
It is obvious that t*exp(-ke*t) is not expontially decreasing.
However, what I said exactly was: 'the tail ... behaves ... like a
(disturbed) monoexponetial function'. In fact, if you plot
t*exp(-ke*t) versus t on a semilogarithmic plot you will not see a
straight line, but it will be much more 'straight' as compared to the
same plot in the linear co-ordinates.
Best regards,
Vladimir
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