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I also agree with this comment regarding " the intent of TK data".
Within the context of a safety assessement(toxicology) study, TK data should
allow the investigator to say something about the observed "exposure" of a
test system to the active agent(s) relative to what one might have expected
based upon a separate, more complete pharmacokinetic characterization. Too
often investigators (companies) try to make toxicity studies into
pharmacokinetic/toxicokinetic studies and end up with confusing and often
conflicting data, a compromised test system or worse. This confusion can
occur even with the use of dedicated satellite groups.
We sometimes make things much more complicated for ourselves than is
Happy New Year!
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