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Hallo,
is there someone with experience in the use of transgenic animals for
special ADME work? For example: distribution in (P-glycoprotein
lacking) mdr1a-knock out mice vs. wild type mice (described by Schinkel
A.H.et al.) , or metabolism (and/or toxicokinetics) in P450-subtype
lacking knock-out mice?
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)