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I am looking for the references that discuss the importance
or effectiveness to monitor the AUC as well as the trough
concentration in vancomycin ( or aminoglycosides) drug monitoring.
I'm looking forward to your kind response.
Yoshitaka Yano Ph.D.
Shionogi Research Laboratory
Shionogi & Co., Ltd.
Osaka, Japan
yoshitaka.yano.-at-.shionogi.co.jp
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I am not aware of any data that describes monitoring the AUC for vancomycin
as a surrogate for effectiveness. Vancomycin displays time-dependent
bacterial kill, and therefore the most important consideration is the
duration that the serum vanc concentration is above the MIC/MBC. There is
becoming a considerable amount of data describing a target AUC for once
daily administration of aminoglycosides. See references ...
Duffull SB et al., Br J Clin Pharmacol 1997; 43:125-135
Begg EJ et al., Br J Clin Pharmac 1995; 39:605-609
Barclay ML et al., Aust NZ J Med 1995; 25:230-235
I hope this is useful.
Steve...
Steve Duffull
Dept of Clinical Pharmacology
Christchurch Hospital
Private Bag 4710, CHCH
NZ
Ph +64 3 364 0900
Fax +64 3 364 0902
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