PharmPK Discussion - A novel Bayesian dose escalation approach - EWOC

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On 13 Aug 1999 at 13:22:24, david_william.tudor.at.pharma.Novartis.com sent the message


Dear All,
Has anyone heard of "a novel Bayesian dose escalation approach, Escalation With
Overdose Control" please ?
Thanks and regards.

David

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On 14 Aug 1999 at 22:22:01, "J.G. Wright" (J.G.Wright.-at-.newcastle.ac.uk) sent the message


Dear David,

The EWOC method is a continual reassessment method suitable for Phase I
trials in life-threatening diseases such as cancer.  Essentially the key
difference between this and the CRM as conceived by O'Quigley, Pepe and
Fisher and modified by numerous subsequent authors is that the loss
function for assigning the next dose is designed so that overdosing is
more serious than under-dosing.  This alteration to the loss function can
be expressed as the expected rate of overdosing.  The paper is

Cancer Phase I trials: Efficient Dose Escalation with overdose control
James Babb, Andre Rogatko and Shelemyahu Zacks
Statistics in Medicine 17,1103-1120 (1998)

The title is perhaps a little misleading as the modification to the loss
function, although sensible, can never actually CONTROL whether or not you
overdose

James

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On 16 Aug 1999 at 23:08:19, Bill Gillespie (bgillespie.-at-.pharsight.com) sent the message


The authors of the paper JG Wright cited also distribute software implementing
EWOC. It is available at http://www.fccc.edu/users/rogatko/.

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