PharmPK Discussion - Acute poisoning

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On 13 Jul 1999 at 22:04:21, KerryLT.aaa.aol.com sent the message


Has anyone had any experience in using induction of CYP450 to treat an acute
poisoning, if so please tell me with what specific chemicals.

Any info would be appreciated!

Thank you

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On 14 Jul 1999 at 23:04:53, Leslie Carstensen Floren (leslief.at.itsa.ucsf.edu) sent the message


Since maximal induction takes several days, this does not seem like a
logical treatment approach for an acute poisoning

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On 15 Jul 1999 at 21:59:51, "Dr. N. Krivoy" (n_krivoy.aaa.rambam.health.gov.il) sent the message


Dear Sirs
I agree with Leslie Floren, the use of CY inducers are not recommended for
acute poisoning. Usualy one should try to inhibit the CY activity. By the
way, alcohol is a good CY inducer.
N.Krivoy MD
Director of Clinical Pharmacology Unit
Rambam Medical Center, Haifa, Israel

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On 16 Jul 1999 at 09:29:13, "Carl Kirkpatrick" (CarlK.aaa.chhlth.govt.nz) sent the message


Dear Kerry

I also agree about the length of time taken to induce enzymes, the
other thing you would have to consider is whether the metabolites are
also toxic eg paracetamol.

Cheers

Carl

Carl Kirkpatrick
Chief Drug Information Pharmacist
Department of Clinical Pharmacology
Christchurch Hospital
PO Box 4710
CHRISTCHURCH
NEW ZEALAND

Ph:  00 64 3 3640 901
fax:  00 64 3 3640 902

"Health is merely the slowest rate possible at which one can die"

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