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Our group would appreciate any suggestions in identifying an inhibitor of
CYP 450 with the following ideal properties.
1. Non-specificity. We are not sure which isozymes are important in the
metabolism of Eucalyptus terpenes by marsupials, but initial data indicate
cross reactivity with human CYP2E1 and rat CYP2C11 and CYP2C6 antibodies.
However, other isozymes may be involved, and at this point we just want to
find an inhibitor of terpene metabolism. We can screen potential inhibitors
using an in vitro microsomal preparation.
2. Relative safety in vivo. Preferably the inhibitor should have no other
pharmacological effects, in particular none on the gastrointestinal system.
3. Potency. Perhaps a suicide inhibitor which covalently (and permanently)
blocks the enzymes.
School of Pharmacy
University of Tasmania
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