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Dear Pharmacokineticists,
I am looking for a software for (De)Convolution as a "stand alone"
programme, which is commercial available (i.e., so called "validated
programme"...) .
As far as I know there are some homemade programmes in the different working
groups in the industry as well as at universities.
Does anybody work with or know (where to bye) stand alone software for
(De)Convolution ?
Best regards, Annke Frick
************************************************
Dr. Annke D. Frick
Clinical Pharmacokinetics (Ph. I/IIa)
Hoechst Marion Roussel Deutschland GmbH, Frankfurt
Phone ++ 49 69 305-82404
Fax ++49 69 305-81990
email annke.frick.-a-.hmrag.com
Location: Bd H840, Room 426
Postcode: 65926
************************************************
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[Two replies - db]
From: "Mark Lovern"
To:
Subject: RE: PharmPK De)Convolution as a "stand alone" programme
Date: Fri, 29 Oct 1999 12:56:28 -0400
X-Priority: 3 (Normal)
Importance: Normal
Dear Annke:
Next month, Pharsight will be releasing WinNonlin 3.1 Enterprise. One of the
functionalities that will be included in this new release is a
state-of-the-art deconvolution analysis tool. The software will also have
the capability to query import, and export data to and from LIMS and other
databases using ODBC.
We will be demonstrating this product at the upcoming AAPS meeting in New
Orleans. So, if you are going to be at the meeting, please drop by our booth
(#311) and we'll be happy to show it to you.
Best Regards,
Mark Lovern, Ph.D.
Scientist, Pharsight Inc.
---
X-Sender: bertlum.-at-.pobox2
Date: Fri, 29 Oct 1999 11:32:52 -0700
To: PharmPK.-at-.boomer.org
From: Bert Lum
Subject: Re: PharmPK De)Convolution as a "stand alone" programme
Anneke
Here is a previous pkgroup e-mail on the deconvolution subject.
Bert Lum
Bert L. Lum, Pharm.D.
Associate Director, Clinical Trials Office, Room H-3249
Clinical Cancer Center at Stanford, Mail Code 5225
Stanford, CA 94305-5225
Phone: 650-498-4536 Fax: 650-498-4696
E-mail: bert.lum.-at-.stanford.edu
---
Date: Wed, 14 Jul 1999 23:06:34 -0500
From: "Jeff Wald"(by way of David_Bourne)
To: Multiple recipients of PharmPK - Sent by
Subject: WinNonlin Deconvolution Question
Dear Colleagues:
The following summary on convolution and deconvolution methods and
references was kindly provided by Bill Gillespie. Updates on our product
releases can always be obtained at our web site www.pharsight.com.
A future release of WinNonlin will implement a deconvolution method. It is a
constrained deconvolution method that produces a smooth estimate of the
input rate which is constrained to be non-negative. The degree of smoothness
may specified by the user via adjustment of a single tuning parameter, or
that parameter may be estimated automatically via cross-validation.
The estimated release date for the WinNonlin version containing the
deconvolution components is December, 1999. Otherwise I am not aware of any
good commercial software products for convolution and deconvolution.
Kinetica implements a relatively crude point-area deconvolution method that
I cannot recommend due to its poor performance with data containing any
realistic amount of variability. If your needs are more immediate, the best
noncommercial endeavors I am familiar with are programs developed by Roman
Hovorka at City University, London
(http://www.city.ac.uk/~er583/mmg/software.html) and Davide Verotta at UCSF.
Some references on their work follows:
R Hovorka, MJ Chappell, KR Godfrey, FN Madden, MK Rouse, PA Soons. CODE: A
deconvolution program implementing a regularisation method of deconvolution
constrained to non-negative values. Description and pilot evaluation.
Biopharm Drug Dispos 19:39-53 (1998).
FN Madden, KR Godfrey, MJ Chappell, R Hovorka, RA Bates. A comparison of six
deconvolution techniques. J Pharmacokin Biopharm 24:283-299 (1996). D
Verotta. Two constrained deconvolution methods using spline functions. J
Pharmacokin Biopharm 21:609-636 (1993).
D Verotta. Estimation and model selection in constrained deconvolution.
Annals Biomed Eng 21:605-620 (1993).
K E Fattinger, D Verotta. A non-parametric subject-specific population
method for deconvolution: I. Description, internal validation and real data
examples. J Pharmacokin Biopharm 23:581-609 (1996).
D Verotta. An inequality-constrained least-squares deconvolution method. J
Pharmacokin Biopharm 17:269-289 (1989)
Jeff Wald, Ph.D. | Manager, Scientific Support Services
Pharsight Corporation | www.Pharsight.Com
Direct: Jeff.Wald.aaa.Pharsight.com | Technical inquiries:
MAD.Support.-at-.Pharsight.com---
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From: "Hans Proost"
Organization: Pharmacy Dept Groningen University
To: PharmPK.-at-.boomer.org
Date: Mon, 1 Nov 1999 08:48:21 MET
Subject: Re: PharmPK De)Convolution as a "stand alone" programme
X-Confirm-Reading-To: "Hans Proost"
X-pmrqc: 1
Priority: normal
Dear Dr. Frick,
I made a program called KinBes for deconvolution and many other
methods in the area of bioavailability, including bioequivalence
evaluation.
This program is commercially available from MediWare. I have
forwarded your message to that company, and they will contact
you as soon as possible.
Best regards,
Johannes H. Proost
Dept. of Pharmacokinetics and Drug Delivery
University Centre for Pharmacy
Groningen, The Netherlands
tel. 31-50 363 3292
fax 31-50 363 3247
Email: j.h.proost.-a-.farm.rug.nl
---
From: "Brian E. Davies"
To:
Subject: Deconvolution
Date: Sun, 31 Oct 1999 16:01:13 -0500
X-Priority: 3
Dear Annke
Another program to consider is Kinetica 2000 which will also be shown at the
upcoming AAPS meeting. Kinetica has always been ahead of Winnonlin and
this latest version increases the gap even wider. The comment made by jeff
Wald at Pharsight - "Otherwise I am not aware of any good commercial
software products for convolution and deconvolution. Kinetica implements a
relatively crude point-area deconvolution method that I cannot recommend due
to its poor performance with data containing any realistic amount of
variability." was just sour grapes at having to sell an inferior product.
Brian Davies
Advanced Biomedical Research, Inc.
Princeton, NJ 08540
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I wanted to be crystal clear that the quote from me shown below is several
months old and was in reference to the then current version of Kinetica. The
makers of Kinetica are in in the best position to descibe the capability of
future products and it is of great value to the user community for them to
communicate it in a forum like this.
Any improvements to the methodology and availability of commercially available
deconvolution software is a bonus to scientists. It serves the pharmaceutical
community and it helps to advance the underlying science.
Regards, Jeff
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[NOTE!!! Send requests to EVANESSEN.at.compuserve.com NOT the list ;-) db]
To everyone interested in deconvolution software,
I can email you a WIN-ZIPPED evaluation-copy of KINBES, the program for
deconvolution and other methods in the area of bioavailability, made by Dr.
Hans Proost.
Kind regards,
Eddy van Essen
MediWare bv
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)