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As most of you know there has been considerable discussion of intestinal
drug transport and efflux over the past few years. Recently AAPS promoted
extensive discussion of these transport systems and also included a genomic
factor in the expression of these systems. My question is has anyone out
there studied what fraction of a given dose is affected by these
transporters as compared to the more "traditional assumption of a passive
mechanism of absorption" and if significant what key factors affect
transport ( H bonding for example or effective molecular size).
I leave aside amino acid transport systems and facilitated diffusion of
nutrients (eg glucose) that have been well characterized over the years.
thanks in advance,
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