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Hello,
Is there any evidence that ketoconazole is transported by P-glycoprotein or
acts as an inhibitor of that transport system?
thanks,
Gary Maier
Sepracor
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Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J
Mechanisms of resistance to azole antifungal agents in Candida
albicans isolates from AIDS patients involve specific multidrug
transporters.
Antimicrob Agents Chemother 1995 Nov;39(11):2378-86
Siegsmund MJ, Cardarelli C, Aksentijevich I, Sugimoto Y, Pastan I,
Gottesman MM
Ketoconazole effectively reverses multidrug resistance in highly
resistant KB cells.
J Urol 1994 Feb;151(2):485-91
Greg Blumenthal (blument1.-at-.niehs.nih.gov)
TEL: 919-541-7791, FAX: 919-541-1479
MD A3-06, NIEHS, P.O.Box 12233, RTP, NC 27709-2233 USA
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Gary,
ketoconazole was shown to be an inhibitor of P-gp. For reference check: Kim RB
et al Pharm Res 1999 Mar;16(3):408-14.
Regards,
Bernhard
Bernhard J. Ladstetter, Ph.D.
Institute of Pharmacokinetics & Metabolism
Merck KGaA
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)