PharmPK Discussion - Midazolam Binding to Plastic or Glass Containers

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On 24 Mar 1999 at 22:21:02, "ROHATAGI, Shashank" (Shashank.ROHATAGI.at.RP-RORER.COM) sent the message


To the Discussion Group:

When the iv solution of midazolam is given orally, is any consideration
given to  the type of container ? In other words, is drug adsorption to
plastic etc. a concern.  How has midazolam been given in previous studies ?

Peter Zannikos, PhD
RPR
Collegeville, PA

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On 25 Mar 1999 at 22:12:47, David_Bourne (david.aaa.pharm.cpb.uokhsc.edu) sent the message

[Two replies - db]

From: "Aucoin, Robert" 
To: "'PharmPK.-a-.pharm.cpb.uokhsc.edu'" 
Subject: RE: PharmPK Re: Midazolam Binding to Plastic or Glass Containers
Date: Thu, 25 Mar 1999 07:33:53 -0600
MIME-Version: 1.0

Since the arrival of Midazolam PO formulation, we no longer use the IV.
Prior to this we used Midazolam mixed in apple juice or with Syrpalta in a
plastic oral syringe.  From a purely clinical standpoint, there was never a
problem with adsorption noted.  This may be due to a very short stay in the
syringe.  When dealing with 2 yr old children, there is a significant
dosage/effect gradient.  Also with the same said 2yr. old the main focus is
to get them to swallow the med. and not blow it back into your face.

thanks................ Robert
Robert Aucoin, RPh                      1-888-765-7428 (Toll free)
Peds Clinical Pharmacist                fax: 225-765-7917
The Children's Center at                e-mail: RAUCOIN.-a-.ololrmc.com
Our Lady of the Lake RMC                pager: 225-338-7573
Baton Rouge, LA  70808

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Date: Thu, 25 Mar 1999 11:17:34 -0500
From: KO-CHIN.KHOO.aaa.roche.com
Subject: Re: PharmPK Re: Midazolam Binding to Plastic or Glass Containers
To: PharmPK.at.pharm.cpb.uokhsc.edu
MIME-version: 1.0
X-Lotus-FromDomain: ROCHE-US-NU

Dr. Rohatagi:

An oral midazolam syrup for use as a premedicant in pediatric patients (6
months to <16 years old) was approved by the FDA on 10/15/98.  This product
is currently available in the pharmacy.

Ko-Chin

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