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I have a little question about the scaling up from intrinsic clearance to
metabolic clearance. In fact, there is a scaling factor based of number of
liver cells per gramm of liver.
I would like know if somebody has this parameter for the mouse, dog, monkey
and espacially in human. I know that for rat, this parameter is equal to 135
millions of cells/ g of liver.
Thank You in advance
Luttringer Olivier e-mail: olivier.luttringer.aaa.roche.com
PRPI-D
F.Hoffmann-La Roche Ltd. phone: +41 61 68 70514
Pharmaceuticals Division
CH-4070 Basel, Switzerland
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Dear Luttringer,
The figure for human is 120 million hepatocytes/g liver. For human please see
Iwatsubo et.al. Prediction of in vivo drug metabolism in the human liver
from in vitro metabolism data, Pharmacol. Ther. Vol. 74, No 2, (1997) 147-171.
For rat, dog and human
Bayliss et.al. Prediction of intrinsic clearance of loxitidine from kinetic
studies in rat, dog and human hepatocytes, Biochem. Soc. trans. 18 (1990)
1198-1199.
Hope this helps.
Chandrani Gunaratna
Chandrani Gunaratna, Ph.D.
Senior Research Chemist
Bioanalytical Systems
2701 Kent Avenue
West Lafayette, IN 47906
Phone: (765)463-4527
E-Mail: prema.-a-.bioanalytical.com
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