PharmPK Discussion - P450 Modulation due to diabetes in mice

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On 23 Jun 1999 at 21:51:57, Kartik shankar (kartik_shankar.aaa.hotmail.com) sent the message


hello,

i am looking for some information on modulation of P450 levels and also
glutathione due to STZ-induced diabetes in the C57bl6 mice. Please give
refrences if possible.

Regards,
Kartik

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On 24 Jun 1999 at 13:05:26, shoaf.at.clinpharm.niaaa.nih.gov sent the message


>i am looking for some information on modulation of P450 levels and also
>glutathione due to STZ-induced diabetes in the C57bl6 mice. Please give
>refrences if possible.

CYP2E1 is induced by mRNA stabilization.
Ma Q, Dannan GA, Guengerich FP, Yang CS. Similarities and differences in
the regulation of hepatic cytochrome P-450 enzymes by diabetes and fasting
in male rats. Biochem Pharmacol 1989;38:3179-84.

The extent of the induction depends on how severely glucose fluctuates.

Song B-J, Veech RL, Saenger P. Cytochrome P450IIE1 is elevated in
lymphocytes from poorly controlled insulin-dependent diabetics. J Clin
Endocrinol Metab 1990;71:1036-40.

Susan Shoaf, Ph.D.
Acting Chief
Unit of Pharmacokinetic Studies
NIAAA/LCS
shoaf.aaa.clinpharm.niaaa.nih.gov
10 Center Dr., MSC-1256
301-496-4936

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