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I am a postdoc working with liposomal delivery systems for
anti-cancer drugs. Are there any books/references that address adequately
pharmacokinetic paramaters for carrier systems (maybe some prodrugs) in a
comprehensive fashion. When we measure tumor, blood, or normal tissue AUCs
for the drug, we are measuring total drug in these compartments. Depending
on the liposome formulation used, there may be varying degrees of
bioavailability of the drug, and this could potentially vary depending on
the compartment as well (i.e. with some formulations greater than 90 % of
the drug AUC found in the blood is entrapped in the liposomal interior and
not available to elicit any response). Of course this results in a
clinical benefit in some instances since drugs can be passively, and more
recently actively, targeted to tumor tissue and away from healthy tissues.
However, it complicates pharmacokinetic analysis. While it is possible in
some cases to measure both free and liposome encapsulated drug in plasma,
it is often difficult, if not impossible, to measure the % encapsulated in
various tissues. These issues complicate traditional pharmacokinetic
analysis of data from what I've read thus far and there are few examples of
books on liposomes dealing with these issues. Does anyone have any
references that may help me out?
Thanks,
Daryl C. Drummond
Dr. Daryl C. Drummond California Pacific Medical Center
Postdoctoral Fellow Liposome Research Laboratory
Papahadjopoulos Laboratory 2200 Webster, 2nd Floor
4259 San Pablo Dam Rd., Apt. #8 San Francisco, CA 94115
El Sobrante, CA 94803 work:(415)923-3500 (ext. 77251)
home: (510)223-0648 fax: (415)561-1344
email: drummond.at.cooper.cpmc.org www site: http://www.cpmc.org/
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)