PharmPK Discussion - Software for keo

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On 14 Oct 1999 at 20:57:47, Korbtham Sathirakul (pyksk.at.mahidol.ac.th) sent the message


Dear all
I am working on the PK/PD of insulin. I  plotted the hyteresis  of the
data. It is anti-clockwise due to time delay. I would like to close the
loop to get the keo parameters. What should be the most appropriate
software to do such analysis? If someone know, please help me.
Bestishes and thank a lot for your recommendation
Korbtham

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On 17 Oct 1999 at 23:05:55, David_Bourne (david.at.boomer.org) sent the message

[A few replies - db]

From: Thomas.Senderovitz.-a-.ferring.com
To: PharmPK.-at-.boomer.org
Subject: RE: PharmPK software for keo
Date: Fri, 15 Oct 1999 08:24:37 +0200

Try WinNonlin.

Regards,

Thomas Senderovitz

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From: "Brian E. Davies" 
To: 
Subject: Re:  PharmPK software for keo
Date: Fri, 15 Oct 1999 09:06:54 -0400
X-Priority: 3

A good software package is KINETICA from the InnaPhase Corporation.  You can
view and test the software by downloading it from their Web site -
www.innaphase.com.

regards

Brian

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From: xwang.aaa.innaphase.com
Reply-To: 
Sender: "Xiaofeng Wang" 
To: 
Subject: RE: PharmPK software for keo
Date: Fri, 15 Oct 1999 16:52:57 -0400
X-Priority: 3 (Normal)
Importance: Normal

Dear Korbtham:
In response to your PharmPK inquiry dated October 14th regarding examining
the hysteresis loops during PK/PD analysis for insulin, you can use either
the Jusko indirect response model or the Sheiner effect compartment model to
conduct your analysis. Kinetica is a software program that provides you with
both models and is developed and supported to 800 organizations in 45
countries by InnaPhase Corporation. Kinetica provides many methods including
those for analyzing the hysteresis loop based on receptor theory. You do not
need to buy the Kinetica software to try this, simply give us a call with
your full address and we will ship you a demo CD-ROM. The demo version
allows you to enter your own data in over 50 templates, run your analysis
and visualize the results.
All current Kinetica users can send an email to support.-a-.innaphase.com for an
updated library of methods and models, which includes updated methods for
convolution and deconvolution. These updated methods are provided in
open-source format so you can see how they have been written and edit them
at your discretion.
Best regards,

Xiaofeng Wang, Ph.D.

Innaphase Corporation
1700 Race Street
Philadelphia, PA 19103
Tel: 215 299 7400
Fax: 215 299 1242
www.innaphase.com
xwang.at.innaphase.com

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