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We have compared the pharmacokinetics and pharmacological of a wild type
and mutant cytokine. We observed a 5 fold difference in serum
concentrations at 5 minutes post i.v. injection, yet preliminary
estimates of neutrophils appear to be the same for the two drugs. We
are confirming our cytokine concentration estimates (dose and serum) but
I would appreciate thoughts on potential physiological explanations for
the apparent differences.
--
Diane Stark, Ph.D.
Xencor
2585 Nina Street
Pasadena CA 91107
Email: dstark.-a-.xencor.com
Telephone: (626) 744 5750
Fax: (626) 744 5757
http://www.xencor.com
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)