PharmPK Discussion - Warfarin -Plasma Flow Value?

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On 3 Sep 1999 at 19:02:51, SHASHIKANTH GANNU (gannusk.-at-.yahoo.com) sent the message


I am creating an pharmacokinetic model for warfarin and I am using the
well stirred venous equilibrium model for hepatic clearance. The
warfarin clearance is plasma clearance. Does anyone know of a reference
for plasma flow to the liver?

Shashikanth Gannu
Dept. Of Applied Pharmaceutical Sciences
Univ. Of Rhode Island
Kingston, RI 02881
Phone: 401 788 9547

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On 6 Sep 1999 at 11:13:03, ml11439.-a-.goodnet.com (Michael J. Leibold) sent the message


Hello Dr.Gannu,

     Human physiology textbooks should be a good source for estimates of
hepatic blood flow. Guyton's Textbook of Medical Physiology lists the
hepatic blood flow as 29% of cardiac output, or 1450 ml/min. This is comprised
of 1100 ml/min from the portal vein and 350 ml/min from the hepatic artery.

      The test also indicates that hepatic blood flow can be measured using
indocyanine green, a dye that is removed only by hepatic metabolism:

   hepatic blood flow = rate dye excretion (mg/min)/A-V difference Dye (mg/ml)
    (ml/min)

     The text references can be examined for more detailed accounts of hepatic
blood flow. Also, Gibaldi & Perrier's Pharmacokinetics has values for liver
blood flow in rats with references.

             Mike Leibold, PharmD, RPh
             ML11439.-a-.goodnet.com

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On 7 Sep 1999 at 23:25:44, "Melethil, Srikumaran K." (MelethilS.aaa.umkc.edu) sent the message


Dear Mr. Gannu,

Blood flow to the liver in human adults is about 1.5 L/min.  Hope this will
help.

Sri Melethil, Ph.D.
Professor of Pharmaceutics and Medicine
University of Missouri-KC
School of Pharmacy
Room 203-B, 5005 Rockhilll Road
Kansas City, MO 64110
816-235-1794 (fax: 816-235-5190)

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