Equations for the Estimation of Creatinine Clearance

 The Cockroft Equation It is adequate for most adults patients with normal muscle mass and serum creatinine, Scr < 5 mg/dL: CLcr (male) = IBW (140 - Age) / (72Scr) CLcr (female) = 0.85 IBW (140 - Age) / (72 Scr)Where: A = age in yrs; IBW = Ideal Body Weight in Kg

 The Sanaka equation For elderly pts (>60) with very low muscle mass and who do not have nephrotic syndrome or severe hepatic disease, the CLcr may be measured directly or estimated by the Sanaka equation (Nephron 1996; 73:137-144 ): CLcr (male) = ABW (19 Alb +32) / 100 Scr CLcr (female) = ABW (13 Alb +29) / 100 Scr Where: Alb = plasma albumin level (g/dL); Scr = serum creatinine (mg/dL). ABW = actual body weight in Kg The metric version of the Sanaka equations CLcr (male) = ABW (2 Alb + 35) / 1.24 Scr CLcr (female) = ABW (Alb + 22) / 0.87 Scr Where: Alb = plasma albumin level (g/dL); Scr = serum creatinine (µm/L). ABW = actual body weight in Kg

 Ideal Body Weight (IBW) (kg) IBW (male) = 50 + 2.3 (H - 60) IBW (female) = 45.5 + 2.3 (H - 60) Where: H = height in inches The metric version IBW (male) = 0.9 H - 88 IBW (female) = 0.9 H - 92 Where: H = height in centimeters.

 Dosing Weight DW = IBW + 0.4 (ABW - IBW) Where: ABW = actual body wt. in Kg

 Jelliffe Equation Good for adult pts with normal muscle mass and Scr less than 5 mg/dL. CLcr (male) = 98 - 0.8 (A - 20) / Scr CLcr (female) = 88 - 0.7 (A - 20) / Scr Where: A = age in yrs CLcr = creatinine clearance in mL/min/1.73 m2

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