Fully Remote -Associate / Director/Principal Scientist Level Pharmacometrics role- Fully Remote (U.S. Only)
Our client is seeking a strong modeler for their exceptional team.This role will work with some of the most highly regarded pharmacometrics leaders in the industry.
The role has flexibility in title and salary but will be an individual contributor and will be hands on with various PK/PD modeling tools such as R, NONMEM, MATLAB etc.
I'm happy to discuss the full role, company and hiring manager should this be of interest. I've included some info from the JD below.
Let me know what you think! Thanks, TJ
- Develop strategies and conduct modeling and simulation to support biomedical decision making
- Develop population pharmacokinetic (PK), pharmacodynamic (PD), exposure-response, disease progression, and/or systems pharmacology models
- Apply models to support decision-making through Monte-Carlo simulation
- Perform model-based meta-analysis of therapeutic area summary-level data
Perform quality control of modeling and simulation analyses - Prepare technical reports, manuscripts, and presentations
- Work collaboratively within assigned agile project team(s) to accomplish team goals
External website https://www.stem-sourcing.com
Contact email address: mreyes@vir.bio - 13th Nov 2024 [3170]
Looking for a Director of Pharmacometrics to join our team. REMOTE or ONSITE
San Francisco, California, United States Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Vir’s clinical-stage portfolio includes infectious disease programs for chronic hepatitis delta and chronic hepatitis B infections, in addition to multiple oncology programs. Vir also has a preclinical portfolio of programs across a range of other infectious diseases and oncologic malignancies.
We believe the success of our colleagues drives the success of our mission. We are committed to creating a company passionate about equality, inclusion, and respect. When everyone feels supported and encouraged to give their best, we will collectively deliver outstanding results.
THE OPPORTUNITY
Vir Biotechnology is looking for a Pharmacometrician to lead our pharmacometrics strategy across therapeutic areas and programs, from early clinical development to market application and commercialization. The Director, Pharmacometrics will join the Clinical Pharmacology department and report to the VP of Clinical Pharmacology.
This role is located in our San Francisco headquarters with an expectation of 4 days per week in office.
WHAT YOU'LL DO
Working in collaboration with the Project Lead Clinical Pharmacologist you will develop and implement model informed drug development (MIDD) plans across projects and disease areas to optimize prospective studies and inform drug development strategy and project decision-making.
With the Project Lead Clinical Pharmacologist you will be responsible for pharmacometrics activities including population pharmacokinetics modeling and simulations, PK/PD and exposure-response.
Conduct modeling and simulations activities for programs across multiple stages of development, from pre-IND through post-marketing.
Present modeling and simulation data as a technical pharmacometrics expert on cross-functional project sub-teams.
Identify opportunities where modeling and simulation can promote the understanding of pharmacological activity, efficacy and safety.
Provide support and help develop our quantitative methodology, pharmacometrics tools, software, hardware, and related business processes.
WHO YOU ARE AND WHAT YOU BRING
PhD with at least 10 years of experience OR MS degree with at least 13 years of experience
Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics or biostatistics.
Experience with quantitative modeling including performing population PK/PKPD analyses using standard pharmacometric software (e.g. NONMEM, R, Monolix, Phoenix) for protein therapeutics (e.g. mAbs, siRNA) and small molecule therapeutics.
Experience managing MIDD (model informed drug development) regulatory strategies together with clinical pharmacology project leads to achieve desired outcomes.
Experience with quantitative systems pharmacology (QSP) and physiologically based pharmacokinetic (PBPK) modeling
Experience with clinical pharmacology studies to support intrinsic/extrinsic factors and the ability to author and defend pharmacometrics components of regulatory filings.
Lead modeling and simulations activities with external CROs.
Mentor junior staff within Clinical Pharmacology.
#LI-225024411_AA1
WHO WE ARE AND WHAT WE OFFER
The expected salary range for this position is $194,500 to $284,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.
Vir's compensation and benefits are aligned with the current market and commensurate with the person's experience and qualifications. All full-time employees receive a package that includes: compensation, bonus and equity as well as many other Vir benefits and perks such as: health, dental, vision, life and disability insurance benefits, non-accrual paid time off, company shut down for holidays, commuter benefits, child care reimbursement, education reimbursement, 401K match and lunch for all onsite employees!
Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
External website https://boards.greenhouse.io/virbiotechnologyinc/jobs/4472046005