PK/PD and Other Jobs

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Contact email address: - 19th Sep 2023 [3148]

Director, Clinical Pharmacology and Pharmacometrics, REMOTE, United States send resume/CV and questions to

Director, clinical pharmacology and pharmacometrics will be responsible to lead projects from early through late-stage clinical development including phase 3 and beyond with an emphasis on clinical dose selection/refinement as well as predictive PK/PD modeling. This will include population and statistically-based methodologies, as well as mechanistic and translational-focused approaches. This role has a highly strategic component but will also include some hands on work in combination with junior scientists and select vendor partners. This is a highly visible and team-facing role.

Responsibilities Include

Requirements include
Contact email address: - 19th Sep 2023 [3147]

Senior Director Clinical Pharmacology role available! My client is a mid sized pharma dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. There is a partnership with large pharma. Incredible financial stability and overall benefits package. This role is onsite in San Diego, CA. Please reach out to me with any interest, questions or leads/referrals. Relocation assistance is available. Job Description Develops overall Clinical Pharmacology scientific strategies for assigned Therapeutic Areas (TA) and contributes to the broader functional strategy. Oversees all aspects of pharmacokinetic and pharmacodynamic activities for clinical development compounds. Key member of clinical protocol development at all stages and ensures appropriate assessment of Clinical Pharmacology endpoints. Represents Preclinical Development as expert to multidisciplinary project teams for assigned TA/Program, advises Sr. Technical Leadership and Executive Management and regularly interfaces with internal and external colleagues to ensure timely and accurate dissemination of Clinical Pharmacology findings.


Contact email address: - 11th Sep 2023 [3146]

Associate Director / Director, Clinical Pharmacology Direct Hire Waltham, MA


Contact email address: - 3rd Aug 2023 [3144]

Research Associate/Postdoctoral Researcher for Interdisciplinary and Translational Research that Integrates Pharmacology, Biology, and Computational Modeling to Facilitate Development of More Efficacious Drug Therapies for Brain Cancer

Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA

Applications are invited for a Research Associate/Postdoctoral Researcher position available at Karmanos Cancer Institute, Wayne State University (Detroit, MI, USA). This is a non-tenure track position, supported by a National Cancer Institute (NCI) funded R01 grant for three years. The goal is to help the postdoctoral researcher to grow and transit into an indepen¬dent principal investigator.

Applications are strongly encouraged for candidates with strong mathematical and computational background who are interested in career development opportunities in the interdisciplinary and translational research that integrates biology, pharmacology, mathematics, and computational modeling to facilitate development of more effective drug therapies for brain cancer.

The postdoctoral researcher will be mentored jointly by Dr. Jing Li (Professor of Oncology and Director of Pharmacology and Metabolomics Core at Karmanos Cancer Institute), Dr. Seongho Kim (Professor and Director of Biostatistics and Bioinformatic Core), and Dr. Hengguang Li (Professor of Mathematics and Chair of Department of Mathematics at Wayne State University).

The postdoctoral researcher will work on a NCI-funded R01 project with the overall goal to develop novel mechanistic, physiologically based pharmacokinetics/pharmacodynamics (PBPK/PD) models for prediction of drug disposition and action in the central nervous system (CNS) in brain cancer patients. Insufficient penetration of potentially effective chemotherapeutic agents across the human blood-brain barrier (BBB) is a huge hurdle to successful treatment of brain cancer. Mechanistic understanding and early prediction of drug penetration into the human CNS is of paramount importance to rational drug development and treatment for brain cancer. Given the fact that drug disposition and action in the human CNS is determined by not only drug properties but also biological system characteristics, preclinical-to-clinical translation of CNS PK/PD is complicated by biological system differences. Hence, the development of innovative approaches is imperative. The in vitro-in vivo extrapolation-PBPK/PD model offers a unique platform that allows simultaneous incorporation of drug- and system-specific parameters into a PK/PD model and enables a priori prediction of in vivo PK/PD processes based on mechanistic scaling of in vitro data (e.g., in vitro enzyme and transporter kinetics, and receptor binding parameters). Our research has been focused on the development of innovative computational models for mechanistic prediction of disposition and action (i.e., PK/PD) of anticancer drugs in the CNS in brain cancer patients. The obtained quantitative information is of enormous value to rational development and optimal use of drug therapies for more efficacious treatment of brain cancer.

A PhD in computational mathematics, computer science, or a related discipline is required. Expertise in R or Matlab is preferred. Knowledge of biology, medicine, or pharmacology is an advantage, though not a requirement. All qualified applicants will receive consideration for employment without regard to race. Interested candidates should apply by sending the application letter and curriculum vita to Dr. Jing Li ( Applications will be considered until the position is filled. The intended start date is September 1. 2023. An earlier or later start date may be considered. Questions should be directed to Dr. Jing Li.

Contact email address: - 15th Jul 2023 [3143]

The Graduate Research Training Program PharMetrX: Pharmacometrics & Computational Disease Modelling is an interdisciplinary PhD program bridging pharmacy and mathematics. PharMetrX aims at understanding the drug-patient-disease interaction by analysing data of drug concentration, effect & disease profiles of pre-/clinical trials and of therapeutic care by developing and applying pharmacometric // PK, PD, disease mathematical & statistical models.

We are currently inviting applications to enrol in the PharMetrX Research+ Program or the PharMetrX Training+ Program.

The PharMetrX Research+ Program (Research & Training & Network) comprises an excellent research environment in the vibrant Berlin/Potsdam area, fascinating and innovative research projects in a highly relevant field, truly transdisciplinary working groups and supervision, an individual mentorship from one of the associated industry partner consortium, a specifically tailored training program of compact academic and industry modules, a network of >100 peers and a competitive 3.5 years fellowship.

The PharMetrX Training+ Program (Training & Network) offers a specifically tailored training program of compact academic and industry modules that convey the foundations in pharmacokinetics & pharmacodynamics, systems biology, statistics, methodological approaches of modelling & simulation etc. as well as a network of >100 peers. It is open for PhD students who have already started their PhD in the field of pharmacometrics since March or will do so soon.

Both programs are open to candidates with a university degree in pharmacy, pharmaceutical sciences, mathematics/statistics, bioinformatics, life sciences or medicine: see

Deadline for applications: 15 September 2023.
PharMetrX is a joint program of Freie Universität Berlin and the University of Potsdam, supported by a consortium of global research-driven pharmaceutical companies.

Charlotte Kloft & Wilhelm Huisinga Program Chairs

External website

Contact email address: - 10th May 2023 [3142]


MMV is a Swiss non-profit foundation whose mission is to reduce the burden of malaria in disease-endemic countries by discovering, developing and delivering new, effective and affordable antimalarial drugs.

Working with drug discovery/development partners in academia and industry, as well as with country-based delivery partners and national ministries of health/malaria control programmes, MMV’s focus extends from the identification of new potential treatments for malaria through to clinical development, regulatory approval and delivery-for-impact in malaria-endemic countries. Since its founding in 1999, MMV and partners have brought forward 11 new medicines that have saved an estimated 2.7 million lives.
We are currently seeking a PKPD postdoc to join our Pharmacometrics team. We are seeking a highly motivated individual who will provide scientific expertise in PKPD modelling as well as modelling and simulation strategy.



  • Ph.D. in Biomedical Science, Pharmacy, Clinical Pharmacology, Biometrics or Computational Engineering
  • 2 years of post-doctorate experience (academia and/or industry) with a proven track record within the duties mentioned above
  • Published peer-reviewed articles
  • Familiarity with the drug development process is an asset
  • Experience working in a cross-functional matrix is also an asset
  • START DATE: As soon as possible

    DEADLINE: May 31, 2023

    External website

    Contact email address: - 9th May 2023 [3141]

    PhD student in microbiology and PKPD mathematical modelling

    Organization/company: Location: INSERM U1070, Poitiers Country: France Website: Mandatory degree: Master 2 Application deadline: 11th June 2023 Starting date: 01/09/2023 Type of contract: Full-time 3 years Funding: ANR/JPIAMR programs Net salary: approximately 1650 €/month

    Offer Description :
    The candidate will work on two international collaborative projects DeCa-P (1) and STARS-TAP (2). These international projects will involve extensive collaboration with the microbiology team of Christian Lesterlin and Sarah Bigot in Lyon, France (3).

    In DeCa-P, we aim to better understand emergence of multi-drug resistant bacteria through study of plasmidic transfer. More precisely we aim to find genetic and environmental factors influencing the plasmidic transfer abilities and rate. To do so, we will focus on the pOXA-48a conjugative plasmid that encodes an OXA-family carbapenemase responsible for carbapenem resistance among Enterobacteriaceae.

    In STARS-TAP, plasmids rather than being foes are turned into friends. Indeed, Targeted-Antibacterial-Plasmids (4) (TAPs) are plasmids that use DNA conjugation to deliver CRISPR/Cas systems to specifically target and kill specific bacterial strains based on their genome. If successful, the use of TAPs would enable preventive removal of strains harboring drug-resistance strains from microbiomes.

    In this project the candidate will have two main tasks: 1) perform in vitro microbiology experiments (MIC, time-kill curves) where the effect of antibiotics on plasmidic transfer ability and rate (DeCa-P) and evaluate the combined efficacy of TAPs with antibiotics (STARS-TAP); 2) develop mathematical models to quantify plasmidic transfer rates, genetic and environmental impact on these rates, TAPs + antibiotic efficacy. The models will be based on in vitro data generated in both projects by the candidate and the project partners.

    The successful candidate will be part of our research unit affiliated to the University of Poitiers and INSERM. We are a transversal group created in 2012 with the aim to optimize antibiotic usage through collaboration between microbiologists, pharmacologists, pharmacometricians, drug formulation researchers, cellular biologists, chemical analysts and clinicians.

    We are developing innovative pharmacokinetic-pharmacodynamic (PKPD) modelling approaches to select the best dosing regimen of antibiotics administered alone or in combination as well as the best route of administration and best formulation. We conduct translational research, from cell culture to patients, by integrating microbiology, analytical chemistry, drug formulation, and in vivo preclinical experiments.


    Qualifications :

    Application procedure:
    Send an email with a cover letter and a CV and one or two professional reference contact to, and a cc to

    External website

    Contact email address: - 8th May 2023 [3140]

    Associate Director Bioanalysis (gn) function at Top Global Player in Germany

    We are currently assigned to recruit an Associate Director Bioanalysis (gn) for a top Global Player in Biopharma in the South of Germany. (being on-site is a must)

    Please find here the details:
    For a globally leading biopharmaceutical company, we are currently looking for an Associate Director Bioanalysis (gn). As such, you are responsible and accountable for a team of highly motivated and skilled professionals and technically lead the bioanalytics team with focus on mass spectrometry.


    Requirements: If interested, please send me your application on

    Dilsad Babayigit CEO ageneo Life Science Experts GmbH

    External website

    3rd May 2023 [3139]

    Parexel is one of the only CROs to provide a broad depth of Clinical Pharmacology, Modeling and Simulation (CPMS) expertise to our clients, and the group is growing its capabilities and expanding globally!

    We currently have tremendous opportunities available for pharmacometrician and clinical pharmacologist to join this extremely collaborative and super friendly team! If you’re looking for an opportunity to be empowered, expand professionally, do more than a narrow scope of work, work alongside a large team of CPMS experts, and provide solutions to a variety of clients with various products in different stages of development across multiple therapeutic areas, apply today at:

    External website

    Contact email address: - 17th Apr 2023 [3138]

    Director/Head of US pharmacometrics role available!
    I am currently recruiting for a large pharma client looking to establish a pharmacometrics group in the US. The successful candidate for this role will have a strong background in quantitative pharmacology, MIDD, and pharmacometrics. Ideally having management experience is also a plus as there will be the responsibility to grow the group and manage individuals career development. This is a unique opportunity to build and grow a group in a highly visible setting with global exposure, but with the stability of a company with a large portfolio of marketed products and robust pipeline. A PhD with NONMEM experience is required along with 7+ years in industry or related field. Will have some hands on modeling responsibilities as well as strategic and managerial component to the role. Please contact me at for more info and we can set up a call to discuss.

    cell is 315-415-4353

    External website

    Contact email address: - 23rd Mar 2023 [3136]

    Postdoctoral position in Drug Metabolism and Pharmacokinetics group is available at The Johns Hopkins University with Johns Hopkins Drug Discovery (JHDD) The candidate will work with a multidisciplinary drugdiscovery team focused on the discovery and development of novel small molecule drugs in the areas of Neurology, Oncology, Gastroenterology, Ophthalmology, and Immunology. The individual selected will be responsible for the analytical method development (MS/MS), pharmacokinetic analyses, drug permeability analyses, drug metabolism (liver microsomes, S9, hepatocytes, etc.), and protein binding studies. In addition, he/she will be expected to also understand the absorption, distribution and elimination principles for application to the characterization of internal drug candidates. JHDD will provide a dynamic research environment including interactions with JHU faculty, medicinal chemists, biochemists, cell biologists and in vivo pharmacologists, as well as interaction with several Pharma industrial partners.
    Requirements for the position include:

    External website

    Contact email address: - 22nd Mar 2023 [3135]

    The University of Minnesota’s College of Pharmacy, Department of Experimental and Clinical Pharmacology (ECP) is seeking a faculty member who will complement our existing strengths in pharmacometrics by contributing field-shaping science to the areas of quantitative systems pharmacology, systems biology, disease modeling, methodological or computational skills related to pharmacometrics. This position aligns with the College of Pharmacy’s strategic plan to build expertise within the theme of precision medicine. Individuals will be expected to apply their pharmacometrics expertise to advance discovery and translation in precision medicine through development of innovative methodological tools and application of physiologic, pharmacokinetic and/or pharmacodynamic modeling.

    Summary of Position:
    The University of Minnesota’s College of Pharmacy, Department of Experimental and Clinical Pharmacology (ECP) invites applications for the position of Assistant or Associate Professor with a focus in Pharmacometrics. This is a 12-month, 1.0 FTE position. Successful candidates will possess an earned doctorate (e.g., Pharm.D., M.D., Ph.D.), and must have research experience that will enable them to establish a strong program of scholarly contributions to the field of pharmacometrics applied to clinical/translational research and precision medicine. The successful applicant will conduct research and teach professional pharmacy students and graduate students in the area of pharmacometrics. They will also provide service to department, collegiate and university initiatives and committees. The candidate will interact with members of other disciplines, schools, centers and research groups at the University to advance our capacity of making significant contributions to quantitative systems pharmacology.

    About the Department:
    The Department of Experimental and Clinical Pharmacology (ECP) is at the forefront of the emerging discipline of experimental pharmacotherapeutics, providing national and international leadership in individualized medicine through prominent research and an excellent graduate program. Groundbreaking and critical research is conducted in the Department of Experimental and Clinical Pharmacology. Our faculty are renowned experts in pharmacogenomics, neuropharmacology, drug metabolism, pharmacometrics, and specific therapeutic areas. Within the department, there is a diverse portfolio of supported research projects with funding from government, corporate, and foundation sources. Faculty members regularly present important findings at national and international conferences, lecture and collaborate across the country, and hold leadership positions in national organizations. Our graduate program offers M.S. and PhD degrees in an innovative, interdisciplinary program that trains students of the highest caliber to conduct research encompassing methodology from basic and clinical pharmacology perspectives. Additionally, ECP faculty contribute significantly to the education of pharmacy students in the College’s professional program through didactic instruction, laboratory experiences, clerkships and clinical rotations.

    To view qualifications and apply, please visit:

    External website

    Last update: Tue 19 Sep 2023 04:25:17 pm

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