PharmPK Discussion - AUC IV versus IP

• On 20 Dec 2000 at 11:42:54, "Sandeep Batra" (prithvi_123.aaa.rediffmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi,
  
  1)If a compound is not metabolised by first pass, does that mean the
  AUC with i.v. and i.p administration of that compound would be same.
  
  2) Or in other words if the AUC by i.p. route is less by about 20 -
  25% as compared to i.v administration: Can we say the drug is getting
  first pass metabolised.
  
  Sandeep.
  
  [1) No; 2) No. There may be incomplete absorption - db]
  
  

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• On 21 Dec 2000 at 10:16:57, bangarurk.aaa.drreddys.com sent the message
  

  
  The following message was posted to: PharmPK
  
  For point no 1 : it may not  happen necessarily  as by giving IV route the
  absorption step is skipped, where as by giving through I.P route absorption
  step  is involved, that determines the extent of absorption, overand above
  this factor, the first-pass metabolism and its extent rules the ratio of
  AUCs following IV and I,P routes.
  
  For Point No. 2 : Not necessarily, refer point 1 which gives the answer.
  
  RK Bangaru
  
  

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