PharmPK Discussion List Archive - 2000
PharmPK Discussion List Frequently Discussed Topics
10-hydroxywarfarin kinetics in humans
14-0H clarithromycin
14C In Vivo Studies
3-compartmental model
5-FU Urine and tissue analysis
A Brain-to-Plasma Ratio Question
A message from the moderator
Absolute oral bioavailability(F) of Roxithromycin
Absorption model
Absorption rate
ADME in critically ill child
ADME/Toxicology in Drug Discovery
Albendazole, albendazole sulfoxide and albendazole sulfone standards
Amprenavir PK
Appearance of metabolites in serum
Applied Dose-Effect Relation?
Aspirin absorption constant
Assay for N telopeptide of type I collagen in serum
AUC IV versus IP
AUC with sd
Audit or monitoring of BE trial
Automated blood sampling in rat
AXSYM Drug Assay System: Equation For Standard Deviation of Assay
BA/BE draft guidance 1999
Baseline Correction for INR
Bile duct cannulation in rats
Bioavailability assay
Bioequivalence
Bioequivalence - parallel design
Bioequivalence criteria
Bioequivalence of inhalation products
Bioequivalence studies - healthy vs patient
Bioequivalence studies in India
Bioequivalence websites
Biological and Physiological Parameters (BALB/c) mice
Blood flow in mouse organs
Blood flow to the liver in different animal species
Blood sampling in rat
Blood Volume
Blood volume from rat
Buccal Drug Delivery
Buflomedil for wound healing
Calculation of loading and maintenance dose
Castration lel in rats
Challenging blood profile
Chemotherapy
Cigarette Smoking Inhalation Chambers
Ciprofloxacin Pharmacokinetics IM administration
Clavulanate Assay
Clofazimine dosing in leprosy
Computer Program for Bioequivalence test
Correlation between rat creatinine and GFR
Creams Bioequivalency
Curcumin-theophylline interaction
Cyclosporine TDM
CYP isozymes
CYP2C8
CYP2E1 and paracetamol
CYP3A4
Cystatin-C as covariate for Kel in PK population models
Dapsone hydroxylamine metabolite
Data Entry - P-Pharm
Data entry in WINNONLIN
Data for absorption model
DDD of nimesulide
DDD of nimesulide
Diazepam Ka question for PK listserv
Diethylstilbestrol HPLC method
Distribution of terbinafine or other lipophilic
Dosage Calculators
Dose adjustment of high dose methotrexate using serum levels
Dose calculation for IM injections
Dose of Galactosamine
Doxorubicin metabolite
DPM to concentration
Dropouts in bioequivalence study
Drug interaction and p-glycoprotein
Drug/metabolites concentration-time profile in urine
Drugs-receptors
EC Bioequivalence
Effect of Bile
Effect of Halothane on Rat Metabolism ?
Enoxaparin dvt dosing in obesity
Enterohepatic Recirculation
Enzyme kinetics
Equations to calculate drug concentrations
Estimating blood levels from plasma levels
Estimation of Css based on bolus Cl value
First pass metabolism - cross species
First pass metabolism in rats
Fitting two peaks in Cp vs time
Fix PK parameters Kinetica
Fluoroquinolone - Theophylline interaction
Food effect study: Washout period
Formulations and Bioequivalence
Free fraction sample preparation
GAM and Predictions
Gender and AUC
Guidelines for off label prescribing
Half-lives in anuria
Help with Norgestimate Assay
Hepatic cell fractions used to predict in vivo metabolism
How many samples per subject
HPLC assay for Paracetamol, Ibuprofen and Caffeine
Hyslop CI and CaCo2 source
In Praise of Bayes
in vitro-in vivo extrapolation -- in vitro t1/2 approach
In vivo in Vitro correlation
in vivo sites of receptor binding
Inability to reach high dose carboplatin AUC
Indirect Response Model
Information about pusulfan?
Infusion and loading doses
Inhibitory constants
InnaPhase News... Free Kinetica 2000 for academics and regulators
Intercompartmental clearance
Intraperitoneal absorption of drugs
Inulin determination in body fluid
Inulin determination in plasma and urine
IP AUC>IV AUC
Isoniazide metabolite request
Itraconazole bioequivalence
IV Drug Delivery System?
IV Injection - Maximum allowable volume
IV model
Ketamine and liver enzyme induction
Kinetica - Macro Language
Kinetica 2000
Kinetica Problem
Levofloxacin elimination
Limit of Total Blood Draw in a BA/BE study
Lipid emulsions of anaesthetic drugs
Liposome metabolism
Log-linear or linear trapezoid
logP of polar phospholipids and other amphiphilic compounds
MacQuan software
Measuring oral absorption
Metabolism of clonidine in humans
Metabolism of morphine
Michael's addition reaction in biological environment-
Michaelis-Menten distribution kinetics
Midazolam metabolite request
Middle ear and sinus fluids
Missing covariates
Model equations
Modelling different administrations forms using winnonlin
ModelMaker 4 modeling software
Models of anesthetic agents
Modified Wagner-Nelson method
Morphine
Morphine and cis-Atracurium
Morphine PK
N-acetyl isoniazide
Nartograstim specific activity
NCA loading+maintainance
Nimesulide synthesis and analysis
Non compartmental, compartmental, population analysis comparisons
Non-linear bioavailability
Non-Linear PKT methods
nor-Femoxetine
Number of samples for two compartment model
Octanol/water coefficient and degree of tissue-distribution
Omeprazole bioavailability
Optimal sampling points
Oral absorption of caffeine and glucose
Organ metabolism
Osteoporosis and rheumatoid arthritis animal model
Palm Pilots for practical pharmacokinetics applications
Paracetamol IV preparation
Paracetamol metabolites
Partial metabolic clearance at steady state
Pediatric PK Study design
Ph.D. in Pharmacokinetics
Pharmaceutical Analysis
Pharmacodynamics
Pharmacokinetics Basic Lecture
Pharmacokinetics of Sparfloxacin
Pharmacologic Tracers
Pharmacy and Research
Phenda Y2k bug
Phlebitis after high pH injection in rats
Phoenix LIMS
Physiologic models
PK of omeprazole
PK Profile of cathepsin K
PK study in dogs
PK/PD Modeling Software
pKa and solubility of quercetin
Placebo tablet supplier
Plasma Css value and Therapeutic Index values of Ibuprofen
PO-kinetics after 2-min infusion?
POP3CM
Population Modeling
Population pharmacokinetics
Posed Stat Question about a Phase I - 3-way cross
Power analysis for a parametric test
Project
Propofol - metabolite
Pseudohypericin, hypericin assay
Pusulfan
Question regarding glomerular filtration process
Questions asked in toxicology
Rate constants
Rate of interstitial fluid flow/exchange
Rectal Absorption Gabapentin
Red blood cell and plasma volume measurements
Red blood cell penetration
Reference for PK parameters not normally distributed
Regarding conduction of a BE study
Relationship between stress and PK
Relative Pharmacokinetics
Renal Impairment PK SMO/CRO
Ropivacaine assay
S-Plus
Saliva theophylline level
Sample collection in clinical trials
Sample size estimate for Population/Individual approach
Schild Plot and Occupancy?
Schild Plot, occupancy, and linearizations
Scientist software
Serum or Plasma Sampling?
Sites for Oncologic PK
Skin blanching
Software for Dosing Antibiotics
Software for Teaching
Source of ciprofloxacin
SPE extraction for cisapride
Statins in saliva
Statistical description of tmax
Statistical Problem?
Statisticians/Modelers
Statistics and understanding data
Statistics software
Statistics software applications
Steady State Determination
Strain difference of protein binding
Stress and Absorption of Fat
Stripping method
T4 levels
Targeted vs Individualized Therapy
TDM computer program
TDM courses and software
TDM of cyclosporine et al.
Teaching software available
Teaching software for PK
Technical help with P-Pharm Licence # P95079
Terms for PK
Testosterone levels in male Wistar rats
Tissue data
TOPFIT
Triexponential - Model example
US vs EU Bioequivalence requirements
Validation of PK software
Vc lower than plasma volume
Venous Irritation and High pH
Volumes of distribution
Weighting
What is in rat plasma?
Which WinNonlin model for TD dosage form.
X-axis for WinNonlin 3.0
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David W. A. Bourne
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