PharmPK Discussion - Blood flow to the liver in different animal species

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On 7 Apr 2000 at 21:52:28, "Jehangir Khan" (jkhan.-a-.synphar.com) sent the message


     I am trying to find references or approximate values of blood flow to
the liver in different animal species especially mice, rat & dogs. Any
information would be of great help.

Thanks

Jehangir K. Khan, M.Pharm, Ph.D
Associate Director
Head, Division of Biopharmaceutics & Pharmacokinetics
NAEJA Pharmaceutical Inc
Tel: 780-462-4044; Fax: 780-461-0196
email: jkhan.-at-.synphar.com

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On 10 Apr 2000 at 21:37:34, David_Bourne (david.aaa.boomer.org) sent the message

[A few replies - mostly the same paper ;-) - db]

Date:   Mon, 10 Apr 2000 09:12:20 +0000
From:   Rujia Xie 
Reply-To: rujia.xie.-at-.biof.uu.se
Organization: Uppsala University
X-Accept-Language: en
To:     PharmPK.aaa.boomer.org
Subject: Re: PharmPK Blood flow to the liver in different animal species

Below article would be helpful.
B. Davies and T. Morris (1993). Physiological parameters in laboratory
animals and humans. Pharm. Res. 10:1093-1095.
--
Rujia Xie, Ph.D.
Division of Biopharmaceutics & Pharmacokinetics
Department of Pharmacy
Uppsala University
Box 580, BMC,
S-751 23, Uppsala, Sweden
Tel: +46- 18 471 4639
Fax: +46- 18 471 4003

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From: "Mendrala, Alan (AL)" 
To: "'PharmPK.-at-.boomer.org'" 
Subject: RE: PharmPK Blood flow to the liver in different animal species
Date: Mon, 10 Apr 2000 07:36:52 -0400

The CRC Handbook of Toxicology has various tables including liver blood flow
to several species.

Al Mendrala
The Dow Chemical Co.
(517) 636-8146
amen.-a-.dow.com

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Date: Mon, 10 Apr 2000 07:47:40 -0400
From: "Cotler, Stanley {NCDS~Nutley}" 
Subject: RE: PharmPK Blood flow to the liver in different animal species
To: "'PharmPK.-a-.boomer.org'" 

A goodrev appeared in Pharm Res Vol 10(7) 1093-1095,1993

Stanley C

Stanley Cotler

Department of Non-Clinical Drug Safety

Phone (973) 235-2857 Fax (973) 235-7010

E-Mail Stanley.Cotler .at.Roche.com

Nutley

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Date: Mon, 10 Apr 2000 08:48:02 -0400
To: PharmPK.aaa.boomer.org
From: "Michael C. Kohn" 
Subject: Re: PharmPK Blood flow to the liver in different animal species

Try B. Davies & T. Morris, Pharmaceut. Rev., 10, 1093--1095 (1993).

Species		Hepatic Artery		Portal Vein

20 g Mouse	0.35 ml/min		1.45 ml/min
250 g Rat	2.0 ml/min		9.8 ml/min
10 kg Dog	79 ml/min		230 ml/min

Michael C. Kohn

Laboratory of Computational Biology and Risk Analysis
National Institute of Environmental Health Sciences
P.O. Box 12233, Mail Drop A3-06
Research Triangle Park, NC 27709-2233

919-541-4929 (voice)
919-541-1470 (Fax)

E-mail: kohn.at.valiant.niehs.nih.gov

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Reply-To: "Estelle Watson" 
From: "Estelle Watson" 
To: 
Subject: Re:  PharmPK Blood flow to the liver in different animal species
Date: Mon, 10 Apr 2000 14:23:28 +0100
X-Priority: 3

Dear Jehangir,
A useful paper for you might be

'Physiological parameters in laboratory animals and humans' by Davies and
Morris 1993 Pharmaceutical research vol. 10 No 7 p1093 to 1095.
it provides organ weights, organ volumes, blood flow though various organs
and other various measurements in mouse, rat, rabbit, monkey,  dog and
human.

Hope this helps

all the best

Estelle Watson

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From: "Stephan, Thomas" 
To: "'PharmPK.aaa.boomer.org'" 
Subject: RE: PharmPK Blood flow to the liver in different animal species
Date: Mon, 10 Apr 2000 07:19:35 -0700

Greetings Jehangir...

      The following reference has been very useful in my work...

Brown, RP et.al.  Physiological Parameter Values For Physiologically Based
Pharmacokinetic Models (1997), Toxicology and Industrial Health, Vol 13, No.
4, 407-483.

      Good luck!!

Regards,
Thomas E. Stephan, Ph.D.
ICOS Corporation

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Subject: Re: PharmPK Blood flow to the liver in different animal species
To: PharmPK.-a-.boomer.org
Bcc:
From: ospiegel.aaa.unmc.edu
Date: Mon, 10 Apr 2000 10:31:57 -0500

A good reference for these values is:
Physiological parameters in laboratory animals and humans, Pharm. Res. 10
(7), 1093-1095, 1993

Ofer Spiegelstein, Ph.D.
Center for Human Molecular Genetics
University of Nebraska Medical Center
Omaha, NE 68198-5455

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On 11 Apr 2000 at 21:44:11, Makoto Niwa(mniwa.at.nipponkayaku.gr.jp) sent the message


Dear Jehangir:

I know some reviews on this issue.

1)Pharm. Res. vol.10,No.7,p1093-1095(1993)
Blood Flow; Mouse 1.8, Rat 13.8 and Dog 309 mL/min

2)J.P.S. vil.72,No.10,p1103-1127(1983)
"Plasma" Flow; Mouse 1.1, Rat 4.7, and Dog 60 mL/min

Best regards,

Makoto Niwa,
Nippon Kayaku Co., Ltd.
e-mail:mniwa.-a-.nipponkayaku.gr.jp
URL:http://member.nifty.ne.jp/mniwa/
Tokyo, Japan

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