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Dear Members,
We would like to carry out PK study of Ciprofloxacin in domestic animals
following I/M administration.
The formulations available in the market are Cirofloxacin Lactate (0.2%)
for IV and Ciprofloxacin HCL for oral and pothalmic use.
Which salt of CIP should we use for IM admn.? Cip lactate 0.2% requires
large volumes to be injected and seems to be impracticable. Can it be
used as concentrated solution? If so, what percentage should we Use?
Any reference, comment on the same are welcome.
Thanks
Bhavsar S.K.
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lactate will be painful and may have other consequences. Acetate or
citrates might be better. HCl would be the better of the two given.
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I'M administration of fluoroquinones may be difficult. I know of no
current formulations that have been used. Ciprofloxacin lactate is
quite acidic and irritating if extravasated. Moreover, the solubility
of ciprofloxacin and other fluoroquinolones decreases with increases in
pH toward neutral pH. Ciprofloxacin injection will precipate if the pH
is adjusted to approximately >= 5. You may try alatrofloxacin which was
solubilized for the addition of cleavable alanine. I'm not sure if this
would be useful for I'M administration though?
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Dear Dr.Bhavsar,
Ciprofloxacin Hydrochloride is soluble in water upto 10mg/ml. You can use
that salt. Hope that helps.
Yati Chugh
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