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I would like to report just a few unimportant errors in my
last email regarding cycloporine TDM:
1) Low-risk patients (eg HLA identical grafts) may receive
"lower" (not higher) doses than high-risk patients (poorly HLA matched grafts).
2) Equation "4" (not 3) may be used to calculate the elmination constant,
and then equation 5 may be used to calculate the dose based on the Ke and
the desired Cminss and Tau(1).
Mike Leibold, PharmD, RPh
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